N-(o-Carboxybenzoyl)-DL-glutamic acid

Base Information

Chemical Name:N-(o-Carboxybenzoyl)-DL-glutamic acid
CAS No.:2353-40-4
Deprecated CAS:2353-40-4
Molecular Formula:
Molecular Weight:0
Hs Code.:
NSC Number:527771,113368
Mol file:2353-40-4.mol

Synonyms:N,N-phthaloyl-L-glutamic acid;N-phthalamoyl-L-glutamic acid;N-phthaloyl-L-glutamic acid;N-phthaloylglutamic acid;N-phthaloylglutamic acid, (DL)-isomer;PhGA;pteroylhexaglutamylglutamic acid

Suppliers and Price of N-(o-Carboxybenzoyl)-DL-glutamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(o-Carboxybenzoyl)-DL-glutamic acid

Chemical Property:

Vapor Pressure:2.99E-17mmHg at 25°C
Boiling Point:639.9°C at 760 mmHg
Flash Point:340.8°C
Density:1.491g/cm³
XLogP3:0.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:295.06920175
Heavy Atom Count:21
Complexity:434

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)NC(CCC(=O)O)C(=O)O)C(=O)O

Technology Process of N-(o-Carboxybenzoyl)-DL-glutamic acid

There total 5 articles about N-(o-Carboxybenzoyl)-DL-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: N-(2-(benzyloxycarbonyl)benzoyl)glutamic acid dibenzyl ester

: 3184-19-8,802560-72-1,2353-40-4
N-(2-carboxybenzoyl)glutamic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; at 20 ℃; for 2h;
DOI:10.1248/cpb.55.651

Reference yield:

: 2528-16-7
o-(benzyloxycarbonyl)benzoic acid

: 3184-19-8,802560-72-1,2353-40-4
N-(2-carboxybenzoyl)glutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: methyl chloroformate; Et₃N / tetrahydrofuran / 0.5 h / 0 °C

1.2: 5.4 percent / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: 99 percent / H₂ / Pd/C / dioxane / 2 h / 20 °C

With hydrogen; triethylamine; methyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1248/cpb.55.651