Ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate

Base Information

• Chemical Name: Ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate
• CAS No.: 163719-69-5
• Molecular Formula: C11H9ClN2O3
• Molecular Weight: 252.657
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10424197
• Wikidata: Q82236665
• Mol file: 163719-69-5.mol

Synonyms:ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate;163719-69-5;ethyl 3-(4-chlorophenyl)-[1,2,4]oxadiazole-5-carboxylate;3-(4-Chloro-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester;3-(4-chlorophenyl)-1,2,4-Oxadiazole-5-carboxylic acid ethyl ester;SCHEMBL3230760;DTXSID10424197;DNTKXLXLDDGVOB-UHFFFAOYSA-N;MFCD05667194;STK349907;AKOS000112012;BS-4665;CS-0298995;FT-0704581;E86961;EN300-230025;A919865;BRD-K47589299-001-01-0;ethyl3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate;ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carbo-xylate

Chemical Property of Ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate

Chemical Property:

• Boiling Point: 368.4±44.0 °C(Predicted)
• PKA: -4.18±0.25(Predicted)
• PSA: 65.22000
• Density: 1.327±0.06 g/cm3(Predicted)
• LogP: 2.56670
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 252.0301698
• Heavy Atom Count: 17
• Complexity: 269

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=NC(=NO1)C2=CC=C(C=C2)Cl

Technology Process of Ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate

There total 5 articles about Ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-chlorobenzamidoxime (5033-28-3) + Ethyl oxalyl chloride (4755-77-5) → ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate (163719-69-5)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 80 ℃; for 3.5h;

DOI:10.1134/S1070428014110232

Reference yield: 85.0%

Ethyl oxalyl chloride (4755-77-5) + 4-chloro-N'-hydroxybenzimidamide (5033-28-3) → ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate (163719-69-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 5 ℃; for 2h; Reflux;

DOI:10.1016/j.jorganchem.2017.04.014

Reference yield: 59.0%

→ ethyl 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate (163719-69-5)

Guidance literature:

upstream raw materials:

4-chlorobenzamidoxime

Ethyl oxalyl chloride

4-Cyanochlorobenzene

4-chloro-N'-hydroxybenzimidamide

Downstream raw materials:

3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carbohydrazide