(1.Alpha.,3a.alpha.,6a.alpha.)-Hexahydro-4-oxo-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicacid-1-ethyl2-(phenylmethyl)ester

Base Information

Chemical Name:(1.Alpha.,3a.alpha.,6a.alpha.)-Hexahydro-4-oxo-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicacid-1-ethyl2-(phenylmethyl)ester
CAS No.:158340-62-6
Molecular Formula:C18H21NO5
Molecular Weight:331.36304
Hs Code.:
Mol file:158340-62-6.mol

Synonyms:(1.Alpha.,3a.alpha.,6a.alpha.)-Hexahydro-4-oxo-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicacid-1-ethyl2-(phenylmethyl)ester

Suppliers and Price of (1.Alpha.,3a.alpha.,6a.alpha.)-Hexahydro-4-oxo-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicacid-1-ethyl2-(phenylmethyl)ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(1R,3aS,6aR)-rel-2-Benzyl1-ethyl4-oxohexahydrocyclopenta[c]pyrrole-1,2(1H)-dicarboxylate 95+%
5g
$ 3572.00

Crysdot
(1R,3aS,6aR)-rel-2-Benzyl1-ethyl4-oxohexahydrocyclopenta[c]pyrrole-1,2(1H)-dicarboxylate 95+%
1g
$ 1191.00

Total 7 raw suppliers

Chemical Property of (1.Alpha.,3a.alpha.,6a.alpha.)-Hexahydro-4-oxo-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicacid-1-ethyl2-(phenylmethyl)ester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:475.04°C at 760 mmHg
PKA:-2.88±0.40(Predicted)
Flash Point:241.096°C
PSA：72.91000
Density:1.26g/cm³
LogP:2.10370

Purity/Quality:

97% ^*data from raw suppliers

(1R,3aS,6aR)-rel-2-Benzyl1-ethyl4-oxohexahydrocyclopenta[c]pyrrole-1,2(1H)-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1.Alpha.,3a.alpha.,6a.alpha.)-Hexahydro-4-oxo-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicacid-1-ethyl2-(phenylmethyl)ester

There total 6 articles about (1.Alpha.,3a.alpha.,6a.alpha.)-Hexahydro-4-oxo-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicacid-1-ethyl2-(phenylmethyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: C₁₅H₂₁NO₄S

: 501-53-1,94274-21-2
benzyl chloroformate

: 402958-21-8,158340-62-6
(1S,3aR,6aS)-4-Oxo-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester

Guidance literature:: C₁₅H₂₁NO₄S; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 70 - 75 ℃; for 8h; Inert atmosphere;

benzyl chloroformate; In dichloromethane; water; at 0 - 20 ℃; for 8h;

Reference yield:

: C₁₀H₁₅NO₃*ClH

: 501-53-1,94274-21-2
benzyl chloroformate

: 158340-62-6
racemic 2-(benzyloxycarbonyl)(1S,3aR,6aS)‐4-(oxo)octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Guidance literature:: With sodium hydroxide; In ethyl acetate; at 0 - 20 ℃; for 4h;

Reference yield:

: (4S,4aS,7aS,7bR)-3a-Methyl-7-oxo-decahydro-3-oxa-8-thia-3b-aza-dicyclopenta[a,e]pentalene-4-carboxylic acid ethyl ester

: 158340-62-6
racemic 2-(benzyloxycarbonyl)(1S,3aR,6aS)‐4-(oxo)octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) AIBN, tri-n-butyltin hydride, 2.) 1 N aq. HCl / 1.) toluene, reflux, 6 h, 2.) r.t., 14 h

2: 50percent aq. NaOH / ethyl acetate / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In ethyl acetate;
DOI:10.1021/jo00089a022