2-(3-Fluorophenyl)-2-methylpropanoic acid

Base Information

• Chemical Name: 2-(3-Fluorophenyl)-2-methylpropanoic acid
• CAS No.: 93748-20-0
• Molecular Formula: C10H11FO2
• Molecular Weight: 182.195
• Hs Code.: 2916399090
• Mol file: 93748-20-0.mol

Synonyms:2-(3-Fluorophenyl)-2-methylpropanoic acid

Chemical Property of 2-(3-Fluorophenyl)-2-methylpropanoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.18790

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(3-Fluorophenyl)-2-methylpropanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-Fluorophenyl)-2-methylpropanoic acid

There total 1 articles about 2-(3-Fluorophenyl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-fluoro-phenyl)-2-methyl-propionitrile (93748-10-8) → 2-(3-fluorophenyl)-2-methylpropanoic acid (93748-20-0)

Guidance literature:

With sulfuric acid; water; In 1,4-dioxane; at 110 ℃; for 16h;

Reference yield:

2-(3-fluorophenyl)-2-methylpropanoic acid (93748-20-0) → 2-(3-fluorophenyl)-2-methylpropanoyl azide (1195179-16-8)

Guidance literature:

2-(3-fluorophenyl)-2-methylpropanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

With sodium azide; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

2-(3-fluorophenyl)-2-methylpropanoic acid (93748-20-0) → 2-(3-fluorophenyl)-2-methylpropanoic acid chloride (1040860-88-5)

Guidance literature:

With thionyl chloride; at 70 ℃; for 1.5h;

upstream raw materials:

2-(3-fluoro-phenyl)-2-methyl-propionitrile

Downstream raw materials:

2-(3-fluorophenyl)-2-methylpropanoic acid chloride

2-(3-fluorophenyl)-2-methylpropanoyl azide

2-(3-fluorophenyl)-2-methylpropanal

diethyl 2-(2-(3-fluorophenyl)-2-methylpropanoyl)malonate

Refernces

• 1、 -. "NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF". Page/Page column 140-141. . Retrieved 2008/12/06.