2-chloro-6-ethynylpyridine

Base Information

• Chemical Name: 2-chloro-6-ethynylpyridine
• CAS No.: 914950-09-7
• Molecular Formula: C7H4ClN
• Molecular Weight: 137.568
• Hs Code.: 2933399990
• Mol file: 914950-09-7.mol

Synonyms:2-chloro-6-ethynylpyridine;(6-Chloropyridin-2-yl)acetylene

Chemical Property of 2-chloro-6-ethynylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 1.71630

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-6-ethynylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-6-ethynylpyridine

There total 3 articles about 2-chloro-6-ethynylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-chloro-6-[(trimethylsilyl)ethynyl]pyridine (1330043-85-0) → 2-chloro-6-ethynylpyridine (914950-09-7)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/acs.orglett.5b01370

Reference yield: 29.0%

→ 2-chloro-6-ethynylpyridine (914950-09-7)

Guidance literature:

Reference yield:

2-bromo-6-chloro-pyridine (5140-72-7) → 2-chloro-6-ethynylpyridine (914950-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2: potassium fluoride / N,N-dimethyl-formamide / 3 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; copper(l) iodide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.5b01370

upstream raw materials:

2-bromo-6-chloro-pyridine

2-chloro-6-[(trimethylsilyl)ethynyl]pyridine

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS JAK INHIBITORS". Page/Page column 86. . Retrieved 2011/09/19.