Technology Process of α,α,2-Trimethylbenzeneacetic acid methyl ester
There total 4 articles about α,α,2-Trimethylbenzeneacetic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(tri-t-butylphosphine)palladium(0); zinc(II) fluoride;
In
N,N-dimethyl-formamide;
at 90 ℃;
DOI:10.1021/acscatal.6b00943
- Guidance literature:
-
2-bromo-2-methylpropionic acid methyl ester;
With
zinc;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Inert atmosphere;
Sealed tube;
2-methylphenyl bromide;
With
di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I);
In
tetrahydrofuran;
at 20 ℃;
for 4h;
Inert atmosphere;
Sealed tube;
DOI:10.1021/jo401476f
- Guidance literature:
-
Methyl isobutyrate;
With
sodium hexamethyldisilazane;
In
toluene;
at 0 ℃;
for 1h;
Inert atmosphere;
Sealed tube;
With
zinc(II) chloride;
In
tetrahydrofuran; toluene;
at 70 ℃;
for 1h;
Inert atmosphere;
Sealed tube;
2-methylphenyl bromide;
With
di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I);
In
tetrahydrofuran; toluene;
at 70 ℃;
for 4h;
Inert atmosphere;
Sealed tube;
DOI:10.1021/jo401476f
