Synthesis of Conformationally Constrained Esters and Amines by Pd-Catalyzed α-Arylation of Hindered Substrates

Article abstract of DOI:10.1021/acscatal.6b00943

The α-arylation of sterically hindered silyl ketene acetals (SKAs) with sterically hindered aryl bromides occurs efficiently using Pd[P(t-Bu)₃]₂ as the optimal catalyst and ZnF₂ as a promoter. Less sensitive P(t-Bu)_3<