6-Bromo-2-(bromomethyl)benzo[b]thiophene

Base Information

• Chemical Name: 6-Bromo-2-(bromomethyl)benzo[b]thiophene
• CAS No.: 895550-11-5
• Molecular Formula: C₉H₆Br₂S
• Molecular Weight: 306.021
• Mol file: 895550-11-5.mol

Synonyms:6-Bromo-2-(bromomethyl)benzo[b]thiophene

Chemical Property of 6-Bromo-2-(bromomethyl)benzo[b]thiophene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-2-bromomethyl-benzo[b]thiophene 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Bromo-2-(bromomethyl)benzo[b]thiophene

There total 4 articles about 6-Bromo-2-(bromomethyl)benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-Brombenzothiophen-2-methanol (374933-76-3) → 6-bromo-2-(bromomethyl)benzo[b]thiophene (895550-11-5)

Guidance literature:

With phosphorus tribromide; In diethyl ether; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b00440

Reference yield:

4-bromo-2-fluorobenzaldehyde (57848-46-1) → 6-bromo-2-(bromomethyl)benzo[b]thiophene (895550-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

3: phosphorus tribromide / diethyl ether / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; phosphorus tribromide; triethylamine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;

DOI:10.1021/acs.jmedchem.5b00440

Reference yield:

6-bromo-benzo[b]thiophene-2-carboxylic acid methyl ester (360576-01-8) → 6-bromo-2-(bromomethyl)benzo[b]thiophene (895550-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

2: phosphorus tribromide / diethyl ether / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; phosphorus tribromide; In tetrahydrofuran; diethyl ether;

DOI:10.1021/acs.jmedchem.5b00440

upstream raw materials:

6-Brombenzothiophen-2-methanol

4-bromo-2-fluorobenzaldehyde

6-bromo-benzo[b]thiophene-2-carboxylic acid methyl ester

Refernces

• 1、 -. "Radioactive iodine labeled compound, and, radioactive pharmaceutical containing the same (by machine translation)". Paragraph 0016; 0037; 0047; 0050. . Retrieved 2018/10/10.
• 2、 -. "CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1". Page/Page column 63. . Retrieved 2008/06/13.