UM729

Base Information

• Chemical Name: UM729
• CAS No.: 1448723-60-1
• Molecular Formula: C20H25N5O2
• Molecular Weight: 367.44
• Mol file: 1448723-60-1.mol

Synonyms:UM729;C07;methyl 4-(3-(piperidin-1-yl)propylamino)-9H-pyrimido[4,5-b]indole-7-carboxylate;4-[[3-(1-Piperidinyl)propyl]amino]-9H-pyrimido[4,5-b]indole-7-carboxylic acid methyl ester

Chemical Property of UM729

Chemical Property:

• PSA: 83.14000
• LogP: 3.19650

Purity/Quality:

99%+, ^*data from raw suppliers

UM729 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of UM729

There total 5 articles about UM729 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.1%

1-(3-aminopropyl)piperidine (3529-08-6) + methyl 4-chloro-9H-pyrimido[4,5-b]indole-7-carboxylate (1096471-98-5) → methyl 4-((3-(piperidin-1-yl)propyl)amino)-9H-pyrimido[4,5-b]indole-7-carboxylate (1448723-60-1)

Guidance literature:

With triethylamine; In methanol; at 140 ℃; for 0.25h; Microwave irradiation;

Reference yield:

4-fluoro-3-nitro-benzoic acid methyl ester (329-59-9) → methyl 4-((3-(piperidin-1-yl)propyl)amino)-9H-pyrimido[4,5-b]indole-7-carboxylate (1448723-60-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 3.5 h / 0 - 20 °C

2.1: zinc; acetic acid / 15.58 h / 100 °C

3.1: formamide / 12 h / 20 - 165 °C

4.1: trichlorophosphate / 16 h / 90 °C

5.1: triethylamine / methanol / 0.25 h / 140 °C / Microwave irradiation

With sodium hydride; acetic acid; triethylamine; zinc; trichlorophosphate; In methanol; formamide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

methyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-3-nitrobenzoate (105600-18-8) → methyl 4-((3-(piperidin-1-yl)propyl)amino)-9H-pyrimido[4,5-b]indole-7-carboxylate (1448723-60-1)

Guidance literature:

Multi-step reaction with 4 steps

1: zinc; acetic acid / 15.58 h / 100 °C

2: formamide / 12 h / 20 - 165 °C

3: trichlorophosphate / 16 h / 90 °C

4: triethylamine / methanol / 0.25 h / 140 °C / Microwave irradiation

With acetic acid; triethylamine; zinc; trichlorophosphate; In methanol; formamide;

upstream raw materials:

4-fluoro-3-nitro-benzoic acid methyl ester

methyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-3-nitrobenzoate

3-ethyl 6-methyl 2-amino-1H-indole-3, 6-dicarboxylate

methyl 4-hydroxy-9H-pyrimido[4,5-b]indole-7-carboxylate

Refernces