2-(2-chlorophenyl)cyclopropanecarboxylic acid

Base Information

• Chemical Name: 2-(2-chlorophenyl)cyclopropanecarboxylic acid
• CAS No.: 1181230-38-5
• Molecular Formula: C10H9ClO2
• Molecular Weight: 196.63
• Mol file: 1181230-38-5.mol

Synonyms:2-(2-chlorophenyl)cyclopropanecarboxylic acid;2-(2-chlorophenyl)cyclopropane-1-carboxylic acid

Chemical Property of 2-(2-chlorophenyl)cyclopropanecarboxylic acid

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-?(2-?Chlorophenyl)?-cyclopropanecarboxyl?icAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-?(2-?Chlorophenyl)?-cyclopropanecarboxyl?ic Acid is used to prepare N-?[(phenylsulfonylamino)?tetrahydronaphthyl]?cyclopropanecarboxamides as potassium channel inhibitors for treatment of cardiac arrhythmias.

Technology Process of 2-(2-chlorophenyl)cyclopropanecarboxylic acid

There total 15 articles about 2-(2-chlorophenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

(+/-)-cis-2-(2-chlorophenyl)cyclopropanecarbonitrile → (+)-(1S,2R)-2-(2-chlorophenyl)cyclopropanecarboxylic acid (1181230-38-5) + (-)-(1R,2S)-2-(2-chlorophenyl)cyclopropanecarboxamide

Guidance literature:

With Rhodococcus sp. AJ₂₇₀; In phosphate buffer; at 30 ℃; for 168h; pH=7.0;

DOI:10.1039/b200110a

Reference yield: 21.0%

2-(2-chloro-phenyl)-cyclopropanecarbonitrile → (+)-(1S,2S)-2-(2-chlorophenyl)cyclopropanecarboxylic acid (1181230-38-5) + (1R,2R)-2-(2-chlorophenyl)cyclopropanecarboxylic acid (1181230-38-5) + (-)-(1R,2R)-2-(2-chlorophenyl)cyclopropanecarboxamide

Guidance literature:

With Rhodococcus sp. AJ₂₇₀; In phosphate buffer; at 30 ℃; for 43h; pH=7.0;

DOI:10.1039/b200110a

Reference yield: 21.0%

2-(2-chloro-phenyl)-cyclopropanecarbonitrile → (+)-(1S,2S)-2-(2-chlorophenyl)cyclopropanecarboxylic acid (1181230-38-5) + (1R,2R)-2-(2-chlorophenyl)cyclopropanecarboxylic acid (1181230-38-5) + (-)-(1R,2R)-2-(2-chlorophenyl)cyclopropanecarboxamide

Guidance literature:

With Rhodococcus sp. AJ₂₇₀; In phosphate buffer; at 30 ℃; for 43h; pH=7.0;

DOI:10.1039/b200110a

upstream raw materials:

trans-2-chlorocinnamic acid

methyl (2E)-3-(2-chlorophenyl)prop-2-enoate

2-chlorostyrene

(2E)-3-(2-chlorophenyl)-N-methoxy-N-methylacrylamide

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