(E)-METHYL 3-(2-CHLOROPHENYL)ACRYLATE

Base Information

• Chemical Name: (E)-METHYL 3-(2-CHLOROPHENYL)ACRYLATE
• CAS No.: 98288-14-3
• Molecular Formula: C10H9ClO2
• Molecular Weight: 196.633
• Hs Code.: 2916399090
• Mol file: 98288-14-3.mol

Synonyms:

Chemical Property of (E)-METHYL 3-(2-CHLOROPHENYL)ACRYLATE

Chemical Property:

• PSA: 26.30000
• LogP: 2.52620

Purity/Quality:

97% ^*data from raw suppliers

(E)-Methyl3-(2-Chlorophenyl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-METHYL 3-(2-CHLOROPHENYL)ACRYLATE

There total 24 articles about (E)-METHYL 3-(2-CHLOROPHENYL)ACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(2-chlorophenyl)acetamide (533-17-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl (2E)-3-(2-chlorophenyl)prop-2-enoate (98288-14-3)

Guidance literature:

N-(2-chlorophenyl)acetamide; With boron trifluoride methanol complex; In methanol; at 65 ℃; Inert atmosphere;

With tert.-butylnitrite; In methanol; at 0 ℃; for 1h; Inert atmosphere;

acrylic acid methyl ester; With palladium diacetate; In methanol; at 20 ℃; for 12.25h; Inert atmosphere;

DOI:10.1002/adsc.201200929

Reference yield: 97.0%

methanol (67-56-1) + trans-2-chlorocinnamic acid (704-96-1,939-58-2) → methyl (2E)-3-(2-chlorophenyl)prop-2-enoate (98288-14-3)

Guidance literature:

With trichlorophosphate; Reflux;

Reference yield: 94.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + o-chloroaniline (95-51-2) → methyl (2E)-3-(2-chlorophenyl)prop-2-enoate (98288-14-3)

Guidance literature:

o-chloroaniline; With tert.-butylnitrite; boron trifluoride diethyl etherate; at -15 - 5 ℃; for 0.583333h;

acrylic acid methyl ester; With (R,R)-N,N'-(2-MeC₆H₄)2-N,N'-(cyclohexane-1,2-diyl)thiourea; palladium diacetate; In methanol; at 20 ℃; for 4h;

DOI:10.1021/ol036182u

upstream raw materials:

2-chloro-benzaldehyde

bromoacetic acid methyl ester

methyl 2-phenylsulfinylacetate

1-chloro-2-(chloromethyl)benzene

Downstream raw materials:

3-chlorophenylpropionic acid methyl ester

dimethyl-3,4-bis(2-chlorophenyl)cyclobutane-1,2-dicarboxylate

(2E)-3-(2-chlorophenyl)-prop-2-en-1-ol