[2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid

Base Information

• Chemical Name: [2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid
• CAS No.: 1431546-20-1
• Molecular Formula: C14H18BFO4
• Molecular Weight: 280.104
• Hs Code.: 2931900090
• Mol file: 1431546-20-1.mol

Synonyms:[2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid

Chemical Property of [2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid

Chemical Property:

• PSA: 55.76000
• LogP: 1.75200

Purity/Quality:

95%+ ^*data from raw suppliers

[2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid

There total 4 articles about [2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(4-bromo-2-fluoro-phenyl)acetic acid (114897-92-6) + bis(pinacol)diborane (73183-34-3) → 2-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid (1431546-20-1)

Guidance literature:

With potassium acetate; In N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

Reference yield: 84.0%

methyl 2-(2-fluoro-4-(4,4 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate (1415960-53-0) → 2-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid (1431546-20-1)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 8h;

Reference yield:

methyl 2-(4-bromo-2-fluoro-phenyl)acetate (193290-19-6) → 2-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid (1431546-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 8 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; lithium hydroxide; In tetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

methyl 2-(4-bromo-2-fluoro-phenyl)acetate

2-(4-bromo-2-fluoro-phenyl)acetic acid

methyl 2-(2-fluoro-4-(4,4 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

bis(pinacol)diborane