Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate

Base Information

• Chemical Name: Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate
• CAS No.: 847862-26-4
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.319
• Mol file: 847862-26-4.mol

Synonyms:Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate;Carbamic acid, (8-anti)-3-azabicyclo[3.2.1]oct-8-yl-, 1,1-dimethylethyl ester

Chemical Property of Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate

Chemical Property:

• PSA: 50.36000
• LogP: 2.22880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate

There total 6 articles about Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

exo-tert-butyl N-(3-benzyl-3-azabicyclo[3.2.1]octan-8-yl)carbamate (847862-25-3) → tert-butyl N-[(1R,5S,8s)-3-azabicyclo[3.2.1]octan-8-yl]carbamate (847862-26-4,847795-98-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 25 ℃; for 3h;

Reference yield:

(rac)-3-benzyl-3-azabicyclo[3.2.1]octan-8-one oxime → tert-butyl N-[(1R,5S,8s)-3-azabicyclo[3.2.1]octan-8-yl]carbamate (847862-26-4,847795-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / Raney nickel / methanol / 1 h

2: dichloromethane / 2 h / 25 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 25 °C

With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

(1R,5S,8s)-3-benzyl-3-azabicyclo[3.2.1]octan-8-amine (847862-24-2) → tert-butyl N-[(1R,5S,8s)-3-azabicyclo[3.2.1]octan-8-yl]carbamate (847862-26-4,847795-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 25 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 25 °C

With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane;

upstream raw materials:

(1R,5S,8s)-3-benzyl-3-azabicyclo[3.2.1]octan-8-amine

exo-tert-butyl N-(3-benzyl-3-azabicyclo[3.2.1]octan-8-yl)carbamate

3-benzyl-N-hydroxy-3-azabicyclo[3.2.1]octan-8-imine

3-benzyl-3-azabicyclo[3.2.1]octan-8-amine

Downstream raw materials:

[(rac)-8-endo-3-(3-methyl-[1,2,4]thiadiazol-5-yl)-3-aza-bicyclo[3.2.1]oct-8-yl]-[8-(2-chloro-4-fluoro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amine

Refernces

• 1、 -. "BRIDGED PIPERIDINE DERIVATIVES". . . Retrieved 2012/09/21.