(R)-4-Amino-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (R)-4-Amino-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1357600-61-3
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.33
• Mol file: 1357600-61-3.mol

Synonyms:(R)-4-Amino-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of (R)-4-Amino-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 293.9±33.0 °C(Predicted)
• PKA: 10.14±0.40(Predicted)
• PSA: 55.56000
• Density: 0.989±0.06 g/cm3(Predicted)
• LogP: 2.61890

Purity/Quality:

99%, ^*data from raw suppliers

(R)-4-Amino-3,3-dimethyl-piperidine-1-carboxylicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-Amino-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about (R)-4-Amino-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tert-butyl (R)-3,3-dimethyl-4-(((R)-1-phenylethyl)amino)piperidine-1-carboxylate (1357396-57-6) → tert-butyl (R)-4-amino-3,3-dimethylpiperidine-1-carboxylate (1357600-61-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 20h;

Reference yield:

tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (324769-06-4) → tert-butyl (R)-4-amino-3,3-dimethylpiperidine-1-carboxylate (1357600-61-3)

Guidance literature:

Multi-step reaction with 3 steps

1: titanium tetrachloride; triethylamine / dichloromethane / 60 °C

2: sodium tetrahydroborate / ethanol / -78 - -20 °C

3: palladium on activated charcoal; hydrogen / methanol

With sodium tetrahydroborate; palladium on activated charcoal; hydrogen; titanium tetrachloride; triethylamine; In methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.11.112

Reference yield:

C20H30N2O2 (1400580-24-6) → tert-butyl (R)-4-amino-3,3-dimethylpiperidine-1-carboxylate (1357600-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / -78 - -20 °C

2: palladium on activated charcoal; hydrogen / methanol

With sodium tetrahydroborate; palladium on activated charcoal; hydrogen; In methanol; ethanol;

DOI:10.1016/j.bmcl.2011.11.112

upstream raw materials:

C₂₀H₃₀N₂O₂

tert-butyl (R)-3,3-dimethyl-4-(((R)-1-phenylethyl)amino)piperidine-1-carboxylate

tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

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