1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester
CAS No.:636568-08-6
Molecular Formula:C12H11FN2O3
Molecular Weight:250.229
Hs Code.:
DSSTox Substance ID:DTXSID401183667
Wikidata:Q27190931
ChEMBL ID:CHEMBL1537402

Synonyms:636568-08-6;1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester;ethyl 1-(4-fluorophenyl)-4-hydroxypyrazole-3-carboxylate;ethyl 1-(4-fluorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate;Ethyl 1-(4-fluorophenyl)-4-hydroxy-pyrazole-3-carboxylate;MLS000775810;SCHEMBL168643;CHEMBL1537402;CHEBI:111314;DTXSID401183667;HMS2713L14;STL305884;AKOS001054912;AB90917;SMR000369384;EN300-234938;AB00613527-02;SR-01000081940;SR-01000081940-1;Q27190931;Z56882802;F1360-0347;1-(4-fluorophenyl)-4-hydroxy-3-pyrazolecarboxylic acid ethyl ester

Suppliers and Price of 1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester 95%+
5g
$ 2015.00

Matrix Scientific
1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester 95%+
2.500g
$ 1334.00

Matrix Scientific
1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester 95%+
1g
$ 611.00

Chemenu
1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylicacidethylester 95%+
250mg
$ 496.00

Chemenu
1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylicacidethylester 95%+
100mg
$ 313.00

Chemenu
1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylicacidethylester 95%+
1g
$ 1561.00

ACHEMBLOCK
1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylicacidethylester 95%
5G
$ 2335.00

ACHEMBLOCK
1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylicacidethylester 95%
1G
$ 735.00

Abosyn
ethyl1-(4-fluorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate 95%-98%
1g
$ 750.00

Total 3 raw suppliers

Chemical Property of 1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

PSA：64.35000
LogP:1.89370
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:250.07537038
Heavy Atom Count:18
Complexity:295

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=NN(C=C1O)C2=CC=C(C=C2)F

Technology Process of 1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester

There total 4 articles about 1-(4-Fluoro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: ethyl 4-chloro-2-(4-fluorophenyl)azo-3-oxo-butanoate

: 636568-08-6
ethyl 1-(4-fluorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate

Guidance literature:: With potassium acetate; In ethanol; for 1h; Reflux;

Reference yield:

: 1361031-17-5
ethyl 4-chloro-2-(4-fluorophenyl)azo-3-oxo-butanoate

: 636568-08-6
ethyl 1-(4-fluorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate

Guidance literature:: With potassium acetate; In ethanol; for 1h; Reflux;

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 636568-08-6
ethyl 1-(4-fluorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; sulfuric acid / dichloromethane; acetic acid / 0.5 h / 0 °C

1.2: 0.33 h / 0 °C

1.3: 1.5 h / 0 - 20 °C

2.1: potassium acetate / ethanol / 1 h / Reflux

With sulfuric acid; potassium acetate; sodium nitrite; In ethanol; dichloromethane; acetic acid;