ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate
CAS No.:1361031-38-0
Molecular Formula:C₁₆H₂₀FN₃O₂
Molecular Weight:305.352
Hs Code.:

Synonyms:ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Suppliers and Price of ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Chemical Property:

Boiling Point:416.7±45.0 °C(Predicted)
Density:1.15±0.1 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

There total 6 articles about ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 4-[2-ethoxyvinyl]-1-(4-fluorophenyl)pyrazole-3-carboxylate

: 124-40-3
dimethyl amine

: 1361031-38-0
ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: ethyl 4-[2-ethoxyvinyl]-1-(4-fluorophenyl)pyrazole-3-carboxylate; dimethyl amine; In ethanol; for 2h;

With sodium cyanoborohydride; In ethanol; for 12h;

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 1361031-38-0
ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; sulfuric acid / dichloromethane; acetic acid / 0.5 h / 0 °C

1.2: 0.33 h / 0 °C

1.3: 1.5 h / 0 - 20 °C

2.1: potassium acetate / ethanol / 1 h / Reflux

3.1: trifluoromethylsulfonic anhydride; 2,6-dimethylpyridine / dichloromethane

3.2: 5 h / 90 °C / Inert atmosphere

4.1: ethanol / 2 h

4.2: 12 h

With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; sulfuric acid; potassium acetate; sodium nitrite; In ethanol; dichloromethane; acetic acid;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1361031-38-0
ethyl 4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; sulfuric acid / dichloromethane; acetic acid / 0.5 h / 0 °C

1.2: 0.33 h / 0 °C

1.3: 1.5 h / 0 - 20 °C

2.1: potassium acetate / ethanol / 1 h / Reflux

3.1: trifluoromethylsulfonic anhydride; 2,6-dimethylpyridine / dichloromethane

3.2: 5 h / 90 °C / Inert atmosphere

4.1: ethanol / 2 h

4.2: 12 h

With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; sulfuric acid; potassium acetate; sodium nitrite; In ethanol; dichloromethane; acetic acid;