2-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-4(1H)-one

Base Information

• Chemical Name: 2-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-4(1H)-one
• CAS No.: 175471-65-5
• Molecular Formula: C10H15N3O5
• Molecular Weight: 257.2432
• DSSTox Substance ID: DTXSID401191000
• Mol file: 175471-65-5.mol

Synonyms:175471-65-5;2'-O-Methyl isocytidine;2-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-4(1H)-one;2-Amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-4-one;2-Amino-1-(2-O-methyl-beta-D-ribofuranosyl)-4(1H)-pyrimidinone;DTXSID401191000;F13473;A900751

Chemical Property of 2-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-4(1H)-one

Chemical Property:

• PSA: 119.83000
• LogP: -1.32770
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 257.10117059
• Heavy Atom Count: 18
• Complexity: 397

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1C(C(OC1N2C=CC(=O)N=C2N)CO)O
• Isomeric SMILES: CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)N=C2N)CO)O

Technology Process of 2-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-4(1H)-one

There total 3 articles about 2-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2'-O-methyl-2,5'-anhydrouridine (175471-64-4) → 2'-O-methylisocytidine (175471-65-5)

Guidance literature:

With ammonia; In methanol; for 120h; Ambient temperature;

DOI:10.1080/07328319608002392

Reference yield:

2'-O-methyl-5'-O-p-tolylsulfonyluridine (175471-63-3) → 2'-O-methylisocytidine (175471-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / DBU / acetonitrile / 48 h / Heating

2: 85 percent / NH₃ / methanol / 120 h / Ambient temperature

With ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; acetonitrile;

DOI:10.1080/07328319608002392

Reference yield:

2'-O-methyluridine (2140-76-3) → 2'-O-methylisocytidine (175471-65-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / pyridine / Ambient temperature; overnight

2: 61 percent / DBU / acetonitrile / 48 h / Heating

3: 85 percent / NH₃ / methanol / 120 h / Ambient temperature

With ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; methanol; acetonitrile;

DOI:10.1080/07328319608002392

upstream raw materials:

2'-O-methyl-2,5'-anhydrouridine

2'-O-methyl-5'-O-p-tolylsulfonyluridine

2'-O-methyluridine

Downstream raw materials:

5'-O-dimethoxytrityl-2'-O-methyl-N²-(N',N'-dimethylformamidine)isocytidine