2'-O-Methyluridine

Base Information

Chemical Name:2'-O-Methyluridine
CAS No.:2140-76-3
Molecular Formula:C10H14N2O6
Molecular Weight:258.231
Hs Code.:29389090
UNII:399VZB6TMB
DSSTox Substance ID:DTXSID10943959
Nikkaji Number:J120.780F
Wikidata:Q15632791
Metabolomics Workbench ID:53677
Mol file:2140-76-3.mol

Synonyms:2'-O-methyluridine;O(2')-methyluridine

Suppliers and Price of 2'-O-Methyluridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2''-O-MethylUridine
50g
$ 1245.00

TCI Chemical
2'-O-Methyluridine >98.0%(HPLC)(T)
5g
$ 200.00

TCI Chemical
2'-O-Methyluridine >98.0%(HPLC)(T)
1g
$ 65.00

SynQuest Laboratories
2'-O-Methyluridine 98.0%
5 g
$ 80.00

Crysdot
1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 98%
10g
$ 180.00

Crysdot
1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 98%
5g
$ 100.00

Chemenu
1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione 95%+
1000g
$ 1552.00

Biosynth Carbosynth
2'-O-Methyluridine
10 g
$ 100.00

Biosynth Carbosynth
2'-O-Methyluridine
25 g
$ 200.00

Biosynth Carbosynth
2'-O-Methyluridine
5 g
$ 60.00

Total 125 raw suppliers

Chemical Property of 2'-O-Methyluridine

Chemical Property:

Appearance/Colour:White solid
Melting Point:154-156 ºC
PKA:9.39±0.10(Predicted)
PSA：113.78000
Density:1.536 g/cm³
LogP:-2.19780
Storage Temp.:Store at 0°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:-1.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:258.08518617
Heavy Atom Count:18
Complexity:385

Purity/Quality:

99% ^*data from raw suppliers

2''-O-MethylUridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): T+
Hazard Codes:T+
Statements: 26/27/28
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1C(C(OC1N2C=CC(=O)NC2=O)CO)O
Isomeric SMILES:CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O
Description 2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. 2'-O-Methyluridine also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands.
Uses Uridine analog. 2'-O-Methyluridine is used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication. Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

Technology Process of 2'-O-Methyluridine

There total 51 articles about 2'-O-Methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 156541-83-2
1'-(3',5'-O-benzyl-2'-O-methyl-β-D-ribofuranosyl)uracil

: 2140-76-3
2'-O-methyluridine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 25 ℃; for 0.5h; under 760 Torr;
DOI:10.1016/S0040-4020(01)80693-1

Reference yield: 95.0%

: 1384271-34-4
C₂₅H₂₈N₂O₇

: 2140-76-3
2'-O-methyluridine

Guidance literature:: With formic acid; palladium on activated charcoal; hydrogen; In water; isopropyl alcohol; for 12h; under 760.051 Torr;
DOI:10.1016/j.tetlet.2012.05.035