Arabinosyl-6-mercaptopurine

Base Information

• Chemical Name: Arabinosyl-6-mercaptopurine
• CAS No.: 892-49-9
• Molecular Formula: C10H12 N4 O4 S
• Molecular Weight: 284.296
• NSC Number: 406021,99193,92429,92428,84321,4911
• Mol file: 892-49-9.mol

Synonyms:arabinosyl 6 mercaptopurine;arabinosyl-6-mercaptopurine

Chemical Property of Arabinosyl-6-mercaptopurine

Chemical Property:

• Vapor Pressure: 1.95E-21mmHg at 25°C
• Boiling Point: 714.7°C at 760 mmHg
• PKA: 8.40±0.20(Predicted)
• Flash Point: 386°C
• PSA: 148.51000
• Density: 2.02g/cm³
• LogP: -0.89960
• Storage Temp.: -20°C
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 284.05792605
• Heavy Atom Count: 19
• Complexity: 409

Purity/Quality:

97% ^*data from raw suppliers

6-Thio-9-(b-D-arabinofuranosyl)purine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=NC(=S)C2=C(N1)N(C=N2)C3C(C(C(O3)CO)O)O

Technology Process of Arabinosyl-6-mercaptopurine

There total 6 articles about Arabinosyl-6-mercaptopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(6-chloropurin-9-yl)-5-hydroxymethyltetrahydrofuran-3,4-diol (2004-06-0,5399-87-1,7596-60-3,23828-03-7) → 6-thio-inosine (574-25-4,892-49-9,4334-79-6,4988-64-1,7687-43-6,10173-26-9,15639-75-5,22746-58-3,26188-04-5,28069-17-2,122557-20-4)

Guidance literature:

With thiourea; In ethanol; at 50 ℃; for 8h;

Reference yield:

→ thioinosine (574-25-4,892-49-9,4334-79-6,4988-64-1,7687-43-6,10173-26-9,15639-75-5,22746-58-3,26188-04-5,28069-17-2,122557-20-4)

Guidance literature:

Thio-aica-ribosid, Ameisensaeureethylester, A., Na-Ethylat;

Reference yield:

9-β-D-arabinofuranosylguanine (38819-10-2) + 6-mercaptopurine (50-44-2) → 9-β-D-arabinofuranosylpurine-6(1H)-thione (892-49-9)

Guidance literature:

With purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei; In aq. phosphate buffer; at 50 ℃; for 4h; pH=6; Enzymatic reaction;

DOI:10.1002/cctc.201800775

upstream raw materials:

2-(6-chloropurin-9-yl)-5-hydroxymethyltetrahydrofuran-3,4-diol

arabinosyl adenine

9-β-D-arabinofuranosylguanine

6-mercaptopurine

Downstream raw materials:

9-β-D-arabinofuranosylpurine-6-carboxamide