GS967

Base Information

• Chemical Name: GS967
• CAS No.: 1262618-39-2
• Molecular Formula: C14H7F6N3O
• Molecular Weight: 347.219
• Mol file: 1262618-39-2.mol

Synonyms:GS967;6-(4-(trifluoroMethoxy)phenyl)-3-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine

Chemical Property of GS967

Chemical Property:

• PKA: -0.41±0.50(Predicted)
• PSA: 39.42000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 4.31370
• Solubility.: insoluble in H2O; ≥13.35 mg/mL in DMSO; ≥25.52 mg/mL in EtOH with ultrasonic

Purity/Quality:

98% min ^*data from raw suppliers

GS967 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhythmic effects by suppressing EAD- and DAD-mediated extrasystolic activity in PFs and PV and SVC sleeve preparations. Selective late INa inhibition with GS967 exerts potent protective effects against ischemia-induced depolarization and repolarization abnormalities in both atria and ventricles.

Technology Process of GS967

There total 1 articles about GS967 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (1166819-53-9) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → 6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (1262618-39-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

Reference yield:

6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (1262618-39-2) → C14H7F6N3O

Guidance literature:

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 130 ℃;

DOI:10.1016/j.bmcl.2016.03.101

upstream raw materials:

6-bromo-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

4-trifluoromethoxyphenylboronic acid

Refernces