1,2,4-Triazolo[4,3-a]pyridine, 6-broMo-3-(trifluoroMethyl)-

Base Information

• Chemical Name: 1,2,4-Triazolo[4,3-a]pyridine, 6-broMo-3-(trifluoroMethyl)-
• CAS No.: 1166819-53-9
• Molecular Formula: C7H3BrF3N3
• Molecular Weight: 266.02
• Hs Code.: 2933990090
• Mol file: 1166819-53-9.mol

Synonyms:1,2,4-Triazolo[4,3-a]pyridine, 6-broMo-3-(trifluoroMethyl)-;6-BroMo-3-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine

Chemical Property of 1,2,4-Triazolo[4,3-a]pyridine, 6-broMo-3-(trifluoroMethyl)-

Chemical Property:

• PKA: -0.83±0.50(Predicted)
• PSA: 30.19000
• Density: 1.96±0.1 g/cm3(Predicted)
• LogP: 2.51060
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,4-Triazolo[4,3-a]pyridine, 6-broMo-3-(trifluoroMethyl)-

There total 1 articles about 1,2,4-Triazolo[4,3-a]pyridine, 6-broMo-3-(trifluoroMethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-hydrazinylpyridine (77992-44-0) + trifluoroacetic anhydride (407-25-0) → 6-bromo-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (1166819-53-9)

Guidance literature:

5-bromo-2-hydrazinylpyridine; trifluoroacetic anhydride; In propyl cyanide; at 0 - 135 ℃; Sealed flask; Inert atmosphere;

With sodium hydrogencarbonate; In water; Product distribution / selectivity;

Reference yield:

(4-cyclopropylphenyl)boronic acid (302333-80-8) + 6-bromo-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (1166819-53-9) → 6-(4-cyclopropylphenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (1262618-41-6)

Guidance literature:

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; toluene; at 90 ℃; for 1h; Inert atmosphere;

Reference yield:

6-bromo-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (1166819-53-9) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → 6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (1262618-39-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

upstream raw materials:

5-bromo-2-hydrazinylpyridine

trifluoroacetic anhydride

Downstream raw materials:

6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

6-(4-cyclopropylphenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

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