(1-(2-Aminoethyl)piperidin-3-yl)methanol

Base Information

• Chemical Name: (1-(2-Aminoethyl)piperidin-3-yl)methanol
• CAS No.: 857637-03-7
• Molecular Formula: C8H18N2O
• Molecular Weight: 158.24
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10656214
• Mol file: 857637-03-7.mol

Synonyms:857637-03-7;[1-(2-aminoethyl)piperidin-3-yl]methanol;(1-(2-Aminoethyl)piperidin-3-yl)methanol;[1-(2-Amino-ethyl)-piperidin-3-yl]-methanol;SCHEMBL3897612;DTXSID10656214;QFUPBMCLHKJMPT-UHFFFAOYSA-N;MFCD09055288;AKOS009610243;SB42372;AM101364;[1-(2-Aminoethyl)-3-piperidinyl]methanol;[1-(2-aminoethyl)-piperidin-3-yl-]methanol;[1-(2-Aminoethyl)piperidin-3-yl]methanol, AldrichCPR

Chemical Property of (1-(2-Aminoethyl)piperidin-3-yl)methanol

Chemical Property:

• Vapor Pressure: 0.00483mmHg at 25°C
• Boiling Point: 245℃
• Flash Point: 102℃
• PSA: 49.49000
• Density: 1.005
• LogP: 0.28760
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 158.141913202
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

98% ^*data from raw suppliers

[1-(2-aminoethyl)piperidin-3-yl]methanol ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CN(C1)CCN)CO

Technology Process of (1-(2-Aminoethyl)piperidin-3-yl)methanol

There total 3 articles about (1-(2-Aminoethyl)piperidin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-hydroxymethylpiperidin-1-ylacetonitrile (857636-98-7) → [1-(2-aminoethyl)-3-piperidin-2-yl]methanol (857637-03-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jm050438f

Reference yield: 76.0%

→ [1-(2-aminoethyl)-3-piperidin-2-yl]methanol (857637-03-7)

Guidance literature:

Reference yield:

3-(hydroxymethy)piperidine (4606-65-9) → [1-(2-aminoethyl)-3-piperidin-2-yl]methanol (857637-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / tetrahydrofuran / 0.5 h / Heating

2: 76 percent / LiAlH₄ / tetrahydrofuran / 5 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm050438f

upstream raw materials:

3-hydroxymethylpiperidin-1-ylacetonitrile

3-(hydroxymethy)piperidine

Refernces

• 1、 -. "ANTHARQUINONE COMPOUNDS AS ANTI CANCER COMPOUNDS". Page/Page column 11; 16-17. . Retrieved 2008/06/13.