Methyl 4-(piperidin-4-ylmethyl)benzoate hydrochloride

Base Information

• Chemical Name: Methyl 4-(piperidin-4-ylmethyl)benzoate hydrochloride
• CAS No.: 333986-70-2
• Molecular Formula: C14H20ClNO2
• Molecular Weight: 269.771
• European Community (EC) Number: 895-197-0
• Mol file: 333986-70-2.mol

Synonyms:333986-70-2;Methyl 4-(piperidin-4-ylmethyl)benzoate hydrochloride;4-Piperidin-4-ylmethyl-benzoic acid methyl ester HCl;4-Piperidin-4-ylmethyl-benzoic acid methyl ester hydrochloride;MFCD02179177;methyl 4-(piperidin-4-ylmethyl)benzoate;hydrochloride;methyl 4-[(piperidin-4-yl)methyl]benzoate hydrochloride;SCHEMBL4777910;IODVBAPWGFQCFX-UHFFFAOYSA-N;AKOS027430309;SB36656;DA-22460;DS-18946;SY109113;CS-0038480;Y10688;EN300-7419039;A918414;Methyl 4-(4-Piperidylmethyl)benzoate Hydrochloride;METHYL 4-(PIPERIDIN-4-YLMETHYL)BENZOATE HCL;F2167-7497;Z3064092214;4-(4-METHOXYCARBONYLBENZYL)PIPERIDINE HYDROCHLORIDE;4-(4-methoxycarbonylbenzyl)piperidine hydrochloride, AldrichCPR

Chemical Property of Methyl 4-(piperidin-4-ylmethyl)benzoate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 3.14610
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 269.1182566
• Heavy Atom Count: 18
• Complexity: 241

Purity/Quality:

99%, ^*data from raw suppliers

4-Piperidin-4-ylmethyl-benzoicacidmethylesterhydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC(=O)C1=CC=C(C=C1)CC2CCNCC2.Cl

Technology Process of Methyl 4-(piperidin-4-ylmethyl)benzoate hydrochloride

There total 5 articles about Methyl 4-(piperidin-4-ylmethyl)benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 4-(bromomethyl)benzoate (2417-72-3) → 4-piperidin-4-ylmethyl-benzoic acid methyl ester hydrochloride (333986-70-2)

Guidance literature:

Reference yield:

4-(diethyoxyphosphorylmethyl)benzoic acid methyl ester (14295-52-4) → 4-piperidin-4-ylmethyl-benzoic acid methyl ester hydrochloride (333986-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; mineral oil;

Reference yield:

4-(4-methoxycarbonylbenzylidene)piperidine-1-carboxylic acid tert-butyl ester (209808-15-1) → 4-piperidin-4-ylmethyl-benzoic acid methyl ester hydrochloride (333986-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; methanol;

upstream raw materials:

Methyl 4-(bromomethyl)benzoate

4-(4-methoxycarbonylbenzylidene)piperidine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-(4-methoxycarbonylbenzyl)piperidine-1-carboxylate

4-(diethyoxyphosphorylmethyl)benzoic acid methyl ester

Downstream raw materials:

4-{1-[(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-piperidin-4-ylmethyl}-benzoic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 333986-70-2 4-PIPERIDIN-4-YLMETHYL-BENZOIC ACID METHYL ESTER HCL

Send

Send

Metric Ton KG G Pound L ML

Send

Send