7-ChloroMethyl 17R-Drospirenone

Base Information

• Chemical Name: 7-ChloroMethyl 17R-Drospirenone
• CAS No.: 932388-89-1
• Molecular Formula: C₂₄H₃₁ClO₃
• Molecular Weight: 402.961
• Mol file: 932388-89-1.mol

Synonyms:7-ChloroMethyl 17R-Drospirenone;(7β,15α,16α)-7-(ChloroMethyl)-15,16-dihydro-17-hydroxy-3-oxo-3'H-cyclopropa[15,16]pregna-4,15-diene-21-carboxylic Acid γ-Lactone;7β-(ChloroMethyl)-15β,16β-Methylene-3-oxo-17β-pregn-4-ene-21,17-carbolactone

Chemical Property of 7-ChloroMethyl 17R-Drospirenone

Chemical Property:

• PSA: 43.37000
• LogP: 4.91490
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99%, ^*data from raw suppliers

7-Chloromethyl17R-Drospirenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Chloromethyl 17R-Drospirenone (Drospirenone EP Impurity H) is one of the two epimeric lactones from Drospirenone (D689500) acidic treatment. Drospirenone impurity.

Technology Process of 7-ChloroMethyl 17R-Drospirenone

There total 2 articles about 7-ChloroMethyl 17R-Drospirenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dihydrospirorenone (90457-65-1,93920-59-3,67372-75-2,67392-87-4) → 7β-chloromethyl-15β,16β-methylene-3-oxo-17β-pregn-4-ene-21,17-carbolactone (932388-89-1,932388-90-4) + 7β-chloromethyl-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone (932388-89-1,932388-90-4)

Guidance literature:

With hydrogenchloride; In acetone; for 2h; Heating;

DOI:10.1016/j.steroids.2006.05.002

Reference yield:

dihydrospirorenone (90457-65-1,93920-59-3,67372-75-2,67392-87-4) → 7β-chloromethyl-15β,16β-methylene-3-oxo-17β-pregn-4-ene-21,17-carbolactone (932388-89-1,932388-90-4) + 7β-chloromethyl-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone (932388-89-1,932388-90-4)

Guidance literature:

With hydrogenchloride; In acetone; for 2h; Heating;

DOI:10.1016/j.steroids.2006.05.002

upstream raw materials:

dihydrospirorenone