17R-Drospirenone

Base Information

Chemical Name:17R-Drospirenone
CAS No.:90457-65-1
Molecular Formula:C24H30O3
Molecular Weight:366.5
Hs Code.:2932206000
Mol file:90457-65-1.mol

Synonyms:17R-Drospirenone;Drospirenone Related Compound A (15 mg) (17-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxo-17beta-pregn-4-ene-21-carboxylic acid, gamma-lactone);[6R-(6α,7α,8β,9α,10β,13β,14α,15α,16α,17α)]-1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-Hexadecahydro-10,13-diMethyl-spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione;Drospirenone Related CoMpound A;17-epi-Drospirenone

Suppliers and Price of 17R-Drospirenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
17R-Drospirenone
25mg
$ 6040.00

Sigma-Aldrich
Drospirenone impurity E
15mg
$ 1160.00

Sigma-Aldrich
Drospirenone impurity E European Pharmacopoeia (EP) Reference Standard
y0001115
$ 190.00

Total 10 raw suppliers

Chemical Property of 17R-Drospirenone

Chemical Property:

PSA：43.37000
LogP:4.30590

Purity/Quality:

98% ^*data from raw suppliers

17R-Drospirenone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A derivative of Drospirenone (D689500) with a reversed configuration of the 17-spirolactone ring had no biological activity. Drospirenone impurity. 17R-Drospirenone (Drospirenone EP Impurity E) is a derivative of Drospirenone (D689500) with a reversed configuration of the 17-spirolactone ring had no biological activity. Drospirenone impurity.

Technology Process of 17R-Drospirenone

There total 59 articles about 17R-Drospirenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.62%

: 1248589-68-5
C₂₆H₃₈O₅

: 90457-65-1,93920-59-3,67372-75-2,67392-87-4
dihydrospirorenone

Guidance literature:: C₂₆H₃₈O₅; With potassium hydroxide; In methanol; water; at 60 ℃; for 2.5h; Reflux;

With water; acetic acid; In methanol; at 50 - 60 ℃; Product distribution / selectivity; Cooling with ice;

Reference yield: 90.0%

: 6β,7β;15β,16β-dimethylene-3-oxo-17α-pregn-4,20-diene-21,17-carbolactone

: 90457-65-1,93920-59-3,67372-75-2,67392-87-4
dihydrospirorenone

Guidance literature:: With hydrogen; platinum on carbon; In ethyl acetate; for 1h; under 75.0075 Torr; Inert atmosphere;

Reference yield: 82.0%

: 889652-27-1
6β,7β;15β,16β-bismethylene-3-oxoandrost-4-ene[17(β-1')spiro-5']-perhydrofuran-2'ε-ol methyl ether

: 90457-65-1,93920-59-3,67372-75-2,67392-87-4
dihydrospirorenone

Guidance literature:: 6β,7β;15β,16β-bismethylene-3-oxoandrost-4-ene[17(β-1')spiro-5']-perhydrofuran-2'ε-ol methyl ether; With Jones reagent; In acetone; at 0 - 5 ℃; for 1h;

With isopropyl alcohol; In water; acetone; at 0 - 5 ℃; for 0.5h; Product distribution / selectivity;