2-Chloro-4-(trifluoroMethyl)anisole, 97%

Base Information

• Chemical Name: 2-Chloro-4-(trifluoroMethyl)anisole, 97%
• CAS No.: 1214340-18-7
• Molecular Formula: C₈H₆ClF₃O
• Molecular Weight: 210.583
• Hs Code.: 2909309090
• Mol file: 1214340-18-7.mol

Synonyms:2-Chloro-4-(trifluoroMethyl)anisole, 97%;2-Chloro-4-(trifluoromethyl)anisole, 2-Chloro-1-methoxy-4-(trifluoromethyl)benzene, 2-Chloro-4-(trifluoromethyl)phenyl methyl ether;3-Chloro-4-methoxybenzotrifluoride

Chemical Property of 2-Chloro-4-(trifluoroMethyl)anisole, 97%

Chemical Property:

• Refractive Index: 1.4755
• PSA: 9.23000
• LogP: 3.36740
• Water Solubility.: Sparingly soluble in water.(0.26 g/L) (25°C),

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-methoxybenzotrifluoride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Technology Process of 2-Chloro-4-(trifluoroMethyl)anisole, 97%

There total 2 articles about 2-Chloro-4-(trifluoroMethyl)anisole, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-4-chlorobenzotrifluoride (121-50-6) → 2-chloro-4-trifluoromethyl-anisole (1214340-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂; aqueous H₂SO₄ / anschliessendes Erwaermen mit wss. H₂SO₄ unter Einleiten von Wasserdampf

With sulfuric acid; sodium nitrite;

DOI:10.1021/ja01151a141

Reference yield:

2-chloro-5-(trifluoromethyl)phenol (40889-91-6) + dimethyl sulfate (77-78-1) → 2-chloro-4-trifluoromethyl-anisole (1214340-18-7)

Guidance literature:

DOI:10.1021/ja01151a141

upstream raw materials:

2-chloro-5-(trifluoromethyl)phenol

dimethyl sulfate

3-amino-4-chlorobenzotrifluoride