121-50-6

Usage

Chemical Properties

CLEAR COLORLESS TO LIGHT YELLOW LIQUID

Uses

2-Chloro-5-trifluoromethylaniline

InChI:InChI=1/C7H5ClF3N/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3H,12H2

Upstream product

• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 1869-22-3 [2-Chloro-5-(trifluoromethyl)phenyl]hydrazine 
• 86398-98-3 2-chloro-4-trifluoromethylphenyl hydrazine 
• 7732-18-5 water 
• 98-56-6 4-chlorobenzotrifluoride 
• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 
• 386-70-9 6-chloro-2-trifluoromethylnitrobenzene 

Downstream Products

• 585-97-7 acetoacetic acid-(2-chloro-5-trifluoromethyl-anilide) 
• 329-33-9 N-acetyl-sulfanilic acid-(2-chloro-5-trifluoromethyl-anilide) 
• 40889-91-6 2-chloro-5-(trifluoromethyl)phenol 
• 39130-13-7 3,5,2'-trichloro-5'-trifluoromethyl-2-propionyloxy-benzoic acid anilide 
• 39119-00-1 Propionic acid 2,4-dibromo-6-(2-chloro-5-trifluoromethyl-phenylcarbamoyl)-phenyl ester 
• 30359-29-6 1-(6-chloro-3-trifluoromethylphenyl)-2-chlorobutan-3-one 
• 39119-12-5 Acetic acid 2,4-dichloro-6-(2-chloro-5-trifluoromethyl-phenylcarbamoyl)-phenyl ester 
• 39118-99-5 Acetic acid 2,4-dibromo-6-(2-chloro-5-trifluoromethyl-phenylcarbamoyl)-phenyl ester 
• 39119-21-6 Acetic acid 2-bromo-4-tert-butyl-6-(2-chloro-5-trifluoromethyl-phenylcarbamoyl)-phenyl ester 
• 39119-13-6 Carbonic acid 2,4-dichloro-6-(2-chloro-5-trifluoromethyl-phenylcarbamoyl)-phenyl ester methyl ester 
• 39130-12-6 3,5-dibromo-2'-chloro-5'-trifluoromethyl-2-methoxycarbonyloxybenzoic acid anilide 
• 39119-20-5 Carbonic acid 2-bromo-4-tert-butyl-6-(2-chloro-5-trifluoromethyl-phenylcarbamoyl)-phenyl ester methyl ester 
• 27916-91-2 α,α-dichloro-β-(2-chloro-5-trifluoromethyl-phenyl)propionitrile 
• 58140-82-2 C₁₆H₈ClF₆N₅ 

Relevant academic research and scientific papers

A metal-organic framework-templated synthesis of γ-Fe2O3 nanoparticles encapsulated in porous carbon for efficient and chemoselective hydrogenation of nitro compounds

The γ-Fe2O3 nanoparticles well dispersed in porous carbon were fabricated via a Fe-based metal-organic framework-templated pyrolysis. The resultant product exhibits excellent catalytic activity, chemoselectivity and magnetic recyclability for the hydrogenation of diverse nitro compounds under mild conditions.

Research on controllable degradation of sulfonylurea herbicides

In order to seek ecologically safer and environmentally benign sulfonylurea herbicides (SU), insight into the structure/bioassay/soil degradation tri-factor relationship was first established. With the introduction of various groups (alkyl, nitro, halogen, cyano etc.) at the 5th position of its benzene ring, structural derivatives of chlorsulfuron were designed, synthesized, and evaluated for their herbicidal activity. The structures of the title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR, mass spectrometry, elemental analysis and X-ray diffraction. Bioassay results confirmed that most derivatives retained their superior herbicidal activities in comparison with chlorsulfuron. After investigating the soil degradation behavior of each molecule under set conditions, it was found that structures with electron-withdrawing substituents at the 5th position of the benzene ring retained their long degradation half-lives, yet the introduction of electron-donating substituents accelerated the degradation rate. These results will provide a valuable clue to further explore the potential controllable degradation of SU and other herbicides, and to discover novel herbicides that are favorable for environmentally and ecologically sustainable development.

PROCESS FOR SYNTHESIS FIPRONIL

The present disclosure relates to a process for trifluoromethylsulfinyl pyrazole compound of formula I, from a compound of formula III, wherein, R, R1 and R2 represent a group containing halogen group respectively and R3 represents a perhaloalkyl.

PROCESS FOR SYNTHESIS OF FIPRONIL

A process for preparation of a trifluoromethylsulfinyl pyrazole compound of formula (I) from a compound of formula (III) is provided, wherein R, R1 and R2 represent a group containing halogen respectively and R3 represents a perhaloalkyl.

Rapid reduction of heteroaromatic nitro groups using catalytic transfer hydrogenation with microwave heating

A method for the rapid, safe reduction of heteroaromatic and aromatic nitro groups to amines is described using catalytic transfer hydrogenation under microwave heating conditions. Commonly available Pd/C or Pt/C catalyst is extremely effective with 1,4-cyclohexadiene as the hydrogen transfer source. In the case of substrates containing potentially labile aromatic halogens, Pt/C is effective and results in little or no dehalogenation. In general, the reactions are complete within 5 min at 120 °C.

Benzo- and azabenzodithiazole compounds

The present invention provides compounds of formula I or a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof and compounds of the formula or a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Processes for preparing pesticidal intermediates

Compounds of formula (I) are prepared by hydrogenolysis of a compound of formula (II): where R1is haloalkyl, haloalkoxy or ?SF5; W is N or CR3; and R2and R3are H or Cl. The compounds of formula (I) can be used as intermediates in the preparation of pesticidally active arylpyrazole compounds.

A simple and convenient method for the reduction of nitroarenes

A variety of nitroarenes such as simple, electron rich and electron poor were reduced on A12O3 support in presence of sodium hydrogen sulphide under microwave condition to give the corresponding aromatic amines in high yields. It is found that the substituents at different positions on nitrobenzene have no influence except 2d on the rate of reaction and yields of product.

Process for preparing aromatic amines

The present invention relates to a process for preparing aromatic amines by reacting an aromatic nitro compound with carbon monoxide in a solvent mixture comprising water and a water-insoluble organic solvent by means of a catalyst comprising palladium and a water-soluble phosphine under a pressure of from 5 to 300 bar and at a temperature of from 50 to 200° C., and separating the aqueous phase and the organic phase.

First Selective Reduction of Aromatic Nitro Compounds Using Water Soluble Catalysts

A new methodology has been developed which involves the reduction of substituted nitro aromatics to substituted anilines using a two phase system with water - soluble palladium catalysts.The nitro group was reduced selectively to an amine in up to 85percent yield whereby other functional groups i.e., ketone, nitrile, chloride and alkene were untouched.