3-Hydroxytetrahydrofuran

Base Information

• Chemical Name: 3-Hydroxytetrahydrofuran
• CAS No.: 84921-89-1
• Molecular Formula: C₄H₈O₂
• Molecular Weight: 88.1063
• Mol file: 84921-89-1.mol

Synonyms:Ai3-28120;Brn 0102545;Einecs 207-219-2;Nsc 71875

Chemical Property of 3-Hydroxytetrahydrofuran

Chemical Property:

• Boiling Point: 181℃
• Flash Point: 81℃
• Density: 1.09

Purity/Quality:

≥99.0% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:

MSDS Files:

Useful:

Technology Process of 3-Hydroxytetrahydrofuran

There total 82 articles about 3-Hydroxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

D,L-1,2,4-butanetriol (3068-00-6,6810-31-7) → 3-Hydroxytetrahydrofuran (453-20-3,84921-89-1,864447-89-2)

Guidance literature:

sulfuric acid; at 140 ℃; under 49.505 Torr; Product distribution / selectivity; Reactive distillation; Intramolecular dehydration;

Reference yield: 87.0%

C13H17NO4 → 3-Hydroxytetrahydrofuran (453-20-3,84921-89-1,864447-89-2)

Guidance literature:

With acetic acid; zinc; In tetrahydrofuran; water; at 60 ℃; for 2h;

DOI:10.1021/jacs.5b07384

Reference yield: 83.0%

homoalylic alcohol (627-27-0) → 3-Hydroxytetrahydrofuran (453-20-3,84921-89-1,864447-89-2)

Guidance literature:

With formic acid; phosphotungstic acid hydrate; dihydrogen peroxide; In dichloromethane; water; at 120 ℃; Temperature; Reagent/catalyst;

upstream raw materials:

3,4-epoxytetrahydrofuran

tetrahydrofuran-3-one

homoalylic alcohol

4-ethoxy-1,2-dibromo-butane

Downstream raw materials:

(R)-3-iodotetrahydrofuran

tetrahydrofuran-3-yl carbonochloridate

Refernces

• 1、 Uozumi,Hayashi. "Asymmetric hydrosilylation of dihydrofurans by use of palladium-MOP catalyst". . p. 2335 - 2338. Retrieved 1993.
• 2、 -. "Preparation method of hydroxyl oxacycloalkane derivative". Paragraph 0049-0070. . Retrieved 2021/08/14.
• 3、 -. "A S - (+) -3 - hydroxy tetrahydrofuran chemical synthesis method". Paragraph 0023-0025. . Retrieved 2019/04/04.