4-(Piperidin-4-ylmethyl)morpholine

Base Information

• Chemical Name: 4-(Piperidin-4-ylmethyl)morpholine
• CAS No.: 81310-62-5
• Molecular Formula: C10H20N2O
• Molecular Weight: 184.282
• Hs Code.: 2934999090
• European Community (EC) Number: 835-487-6
• DSSTox Substance ID: DTXSID20510232
• Wikidata: Q82368390
• Mol file: 81310-62-5.mol

Synonyms:4-(piperidin-4-ylmethyl)morpholine;81310-62-5;4-[(Piperidin-4-yl)methyl]morpholine;MFCD05215184;SCHEMBL529719;4-(4-Piperidylmethyl)morpholine;DTXSID20510232;DEZJKGVJDMAGPI-UHFFFAOYSA-N;4-Piperidin-4-ylmethyl-morpholine;AC9775;AKOS000123581;BS-13823;SY173472;BB 0220161;CS-0155213;FT-0765334;EN300-42119;J-513828;Z317037040

Chemical Property of 4-(Piperidin-4-ylmethyl)morpholine

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Boiling Point: 275.081°C at 760 mmHg
• Flash Point: 120.165°C
• PSA: 24.50000
• Density: 0.998g/cm³
• LogP: 0.58490
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 184.157563266
• Heavy Atom Count: 13
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

4-(4-piperidinylmethyl)morpholine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1CN2CCOCC2

Technology Process of 4-(Piperidin-4-ylmethyl)morpholine

There total 5 articles about 4-(Piperidin-4-ylmethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(morpholin-4-ylmethyl)piperidine-1-carboxylate (340962-93-8) → 4-[(piperidin-4-yl)methyl]morpholine (81310-62-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(00)00702-2

Reference yield:

4-piperidinemethanol (6457-49-4) → 4-[(piperidin-4-yl)methyl]morpholine (81310-62-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / CH₂Cl₂

2: 100 percent / ClCOCOCl; DMSO; Et₃N / CH₂Cl₂

3: NaCNBH₃; CF₃CH₂OH; 3A sieves

4: 100 percent / CF₃COOH / CH₂Cl₂

With oxalyl dichloride; 2,2,2-trifluoroethanol; 3 A molecular sieve; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In dichloromethane; 2: Swern oxidation;

DOI:10.1016/S0960-894X(00)00702-2

Reference yield:

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6) → 4-[(piperidin-4-yl)methyl]morpholine (81310-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / ClCOCOCl; DMSO; Et₃N / CH₂Cl₂

2: NaCNBH₃; CF₃CH₂OH; 3A sieves

3: 100 percent / CF₃COOH / CH₂Cl₂

With oxalyl dichloride; 2,2,2-trifluoroethanol; 3 A molecular sieve; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In dichloromethane; 1: Swern oxidation;

DOI:10.1016/S0960-894X(00)00702-2

upstream raw materials:

tert-butyl 4-(morpholin-4-ylmethyl)piperidine-1-carboxylate

4-piperidinemethanol

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

tert butyl 4-formylpiperidine-1-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 81310-62-5 4-(PIPERIDIN-4-YLMETHYL)MORPHOLINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send