N-Boc-4-piperidinemethanol

Base Information

• Chemical Name: N-Boc-4-piperidinemethanol
• CAS No.: 123855-51-6
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.293
• Hs Code.: 29339900
• European Community (EC) Number: 639-271-0
• DSSTox Substance ID: DTXSID70377291
• Nikkaji Number: J3.014.454F
• Wikidata: Q72450471
• ChEMBL ID: CHEMBL4911781
• Mol file: 123855-51-6.mol

Synonyms:123855-51-6;N-Boc-4-piperidinemethanol;tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate;1-Boc-4-piperidinemethanol;1-N-Boc-4-hydroxymethyl-piperidine;MFCD02094488;n-boc-4-hydroxymethylpiperidine;1-boc-4-hydroxymethylpiperidine;1-(tert-Butoxycarbonyl)-4-piperidinemethanol;N-(tert-Butoxycarbonyl)-4-piperidinemethanol;1-PIPERIDINECARBOXYLIC ACID, 4-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER;4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester;N-Boc-4-piperidinmethanol;1-(tert-Butoxycarbonyl)-4-(hydroxymethyl)piperidine;1-boc-4-hydroxymethyl-piperidine;1,1-dimethylethyl 4-(hydroxymethyl)-1-piperidinecarboxylate;4-Hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester;n-boc-4-hydroxylmethylene-piperidine;tert-Butyl 4-(hydroxymethyl)-1-piperidinecarboxylate;N-tert-Butyloxycarbonyl-4-piperidinemethanol;l-boc-piperidine-4-methanol;n-boc-4-piperidine methanol;N-boc-piperidine-4-methanol;N-BOC-4-piperidinylcarbinol;tert-butyl 4-(hydroxymethyl)piperidinecarboxylate;1-Boc-piperidine-4-methanol;N-Boc-4-Piperidinyl methanol;SCHEMBL190460;* n-boc-4-piperidinemethanol;F3310-0566;CHEMBL4911781;DTXSID70377291;CTEDVGRUGMPBHE-UHFFFAOYSA-N;1-Boc-4-(hydroxymethyl)piperidine;N-Boc-4-Piperidinemethanol, 97%;BCP23137;STL066885;1-N-Boc-4-(Hydroxymethyl)piperidine;AKOS000501318;AC-1097;CS-W009215;N-t-butoxycarbonyl-4-piperidinemethanol;PB19967;N-t-butoxycarbonyl-4-piperidine-methanol;N-tert-butoxycarbonyl4-piperidinemethanol;N-tert-Butoxycarbony-4-piperidinemethanol;N-tert-butoxycarbonyl-4-piperidinemethanol;N-tert-butoxylcarbonyl4-piperidinemethanol;SY005902;1-(t-butoxycarbonyl)-4-piperidinemethanol;1-tert-Butoxycarbonyl-4-piperidinemethanol;1-tert-butoxycarbonyl-piperidin-4-methanol;1-tert-butoxycarbonylpiperidine-4-methanol;N-t-Butyloxycarbonylpiperidin-4-ylmethanol;N-tert-butoxylcarbonyl-4-piperidinemethanol;1-tert-butoxycarbonyl-piperidine-4-methanol;1-tert-butoxycarbonylpiperidin-4-ylmethanol;n-(tertbutoxycarbonyl)-4-piperidinemethanol;1-(tert-butoxycarbonyl)piperidine-4-methanol;1-t-butoxycarbonyl-4-hydroxymethylpiperidine;AM20080179;B2364;BB 0263070;FT-0630289;N-t-butoxycarbonyl-4-hydroxymethyl piperidine;(1-tert-butoxycarbonylpiperidin-4-yl)methanol;1-(t-Butoxycarbonyl)4-hydroxymethylpiperidine;1-t-Butoxycarbonyl-4-hydroxymethyl-piperidine;EN300-50679;N-(tert-butoxycarbonyl)piperidin-4-ylmethanol;VU0610065-1;1-(t-Butoxycarbonyl)-4-hydroxymethylpiperidine;1-t-butoxycarbonyl-4-(hydroxymethyl)piperidine;1-tert-butoxycarbonyl-4-hydroxymethylpiperidine;4-hydroxymethyl-1-tert-butoxycarbonylpiperidine;A25756;t-butyl 4-hydroxymethyl-1-piperidinecarboxylate;1-(t-Butoxycarbonyl)-4-hydroxymethyl-piperidine;1-(tertbutoxycarbonyl)-4-hydroxymethylpiperidine;1-tert-butoxycarbonyl-4-hydroxymethyl piperidine;1-tert-Butyloxycarbonyl-4-hydroxymethylpiperidine;4-hydroxymethyl-1-tert-butyloxycarbonylpiperidine;N-tert-butyloxycarbonyl-4-hydroxymethylpiperidine;t-butyl 4-(hydroxymethyl)piperidin-1-carboxylate;tert-butyl 4-(hydroxymethyl)piperdinecarboxylate;1-(t-butoxycarbonyl)-4-(hydroxymethyl)piperidine;1-(tert-butoxycarbonyl)-4-hydroxymethylpiperidine;5X-0704;t-butyl 4-(hydroxymethyl)-1-piperidinecarboxylate;tert-butyl 4-hydroxymethyl-1-piperidinecarboxylate;tert-butyl 4-hydroxymethylpiperidine-1-carboxylate;Q-102747;tert-BUTOXYCARBONYL-4-HYDROXYMETHYL-PIPERIDINE;tert-butyl 4(hydroxymethyl)-1-piperidinecarboxylate;tert-Butyl 4(hydroxymethyl)piperidine-1-carboxylate;tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate;1-(tert-butoxycarbonyl)-4-(hydroxymethyl)-piperidine;1-(Tert-butyloxycarbonyl)-4-(hydroxymethyl)piperidine;tert-butyl 4-(hydroxymethyl)-piperidine-1-carboxylate;Tert-butyl 4-(hydroxymethyl)piperidin-1-ylcarboxylate;tert-butyl-4-(hydroxymethyl)-1-piperidine carboxylate;4-hydroxymethyl-piperidine-1-carboxylic acid t-butylester;tertiary butyl 4-(hydroxymethyl)piperidine-1-carboxylate;Z223656778;1,1-dimethylethyl 4-(hydroxymethyl)piperidine-1-carboxylate;1-(1,1-Dimethylethyloxycarbonyl)-4-hydroxymethylpiperidine;4-hydroxymethyl-piperidine-1-carboxylic acid t-butyl ester;4-hydroxymethyl-piperidine-1-carboxylic acid tert-butylester;T-BUTYL 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;1,1-dimethylethyl 4-(hydroxymethyl)-1-piperidine-carboxylate;4-(Hydroxymethyl)-1-piperidinecarboxylic acid tert-butyl ester;4-(hydroxymethyl)piperidine-1-carboxilic acid tert-butyl ester;4-(hydroxymethyl)piperidine-1-carboxylic acid tert-butyl ester;4-hydroxymethyl-piperidin-1-carboxylic acid tert-butyl ester;4-hydroxymethyl-piperidine-1-carboxylic acid tert butyl ester;4-Hydroxymethyl-piperidine-1-carboxylic acid, tert-butyl ester;4-hydroxymethylpiperidine-1-carboxylic acid, 1,1-dimethylethyl ester;tert-butyl 4-(hydroxymethyl)tetrahydro-1(2h)-pyridinecarboxylate

Chemical Property of N-Boc-4-piperidinemethanol

Chemical Property:

• Vapor Pressure: 6.41E-05mmHg at 25°C
• Melting Point: 78-82 °C
• Refractive Index: 1.479
• Boiling Point: 308 °C at 760 mmHg
• PKA: 14.94±0.10(Predicted)
• Flash Point: 140.1 °C
• PSA: 49.77000
• Density: 1.059 g/cm³
• LogP: 1.56370
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 215.15214353
• Heavy Atom Count: 15
• Complexity: 214

Purity/Quality:

98% Min ^*data from raw suppliers

N-Boc-4-piperidinemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)CO
• Uses: Involved in the synthesis of bradycardic agents.

Technology Process of N-Boc-4-piperidinemethanol

There total 35 articles about N-Boc-4-piperidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6)

Guidance literature:

With borane-THF; In tetrahydrofuran;

DOI:10.1016/S0960-894X(01)00661-8 DOI:10.1016/j.bmcl.2003.12.006

Reference yield: 100.0%

4-piperidinemethanol (6457-49-4) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6)

Guidance literature:

In dichloromethane;

DOI:10.1016/S0960-894X(00)00702-2

Reference yield: 100.0%

tert butyl 4-formylpiperidine-1-carboxylate (137076-22-3) → tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 25 ℃; for 1h;

DOI:10.1016/j.ejmech.2018.03.024

upstream raw materials:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

4-piperidinemethanol

di-tert-butyl dicarbonate

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Downstream raw materials:

4-(1-t-butoxycarbonylpiperidin-4-ylmethoxy)benzaldehyde

tert-butyl 4-(bromomethyl)piperidine-1-carboxylate

N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine

7-(1-(tert-butoxycarbonyl)piperidin-4-ylmethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroxyquinazolin-4-one

Refernces

• 1、 Waterhouse,Collier,O'Brien. "Synthesis of 1-(trans-[123I]Iodopropen-2-yl)-4- (4-cyanophenoxymethyl)piperidine: A selective sigma receptor radioligand for SPECT". . p. 215 - 226. Retrieved 1996.
• 2、 Ashford, Mark E.,Nguyen, Vu H.,Greguric, Ivan,Pham, Tien Q.,Keller, Paul A.,Katsifis, Andrew. "Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands". . p. 783 - 794. Retrieved 2014.
• 3、 Kaicharla, Trinadh,Ngoc, Trung Tran,Teichert, Johannes F.,Tzaras, Dimitrios-Ioannis,Zimmermann, Birte M.. "A Bifunctional Copper Catalyst Enables Ester Reduction with H2: Expanding the Reactivity Space of Nucleophilic Copper Hydrides". supporting information. p. 16865 - 16873. Retrieved 2021/10/20.
• 4、 Murugesan, Vetrivelan,Ganguly, Anirban,Karthika, Ardra,Rasappan, Ramesh. "C-H Alkylation of Aldehydes by Merging TBADT Hydrogen Atom Transfer with Nickel Catalysis". supporting information. p. 5389 - 5393. Retrieved 2021/07/21.