8-Dechloro-9-chloro-N-methyl Desloratadine

Base Information

Chemical Name:8-Dechloro-9-chloro-N-methyl Desloratadine
CAS No.:38092-88-5
Molecular Formula:C₂₀H₂₁ClN₂
Molecular Weight:324.853
Hs Code.:
DSSTox Substance ID:DTXSID00546059
Mol file:38092-88-5.mol

Synonyms:8-Dechloro-9-chloro-N-methyl Desloratadine;38092-88-5;14-chloro-2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene;DTXSID00546059;9-chloro-11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 9-chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-;5H-Benzo[5,6]cyclohepta[1,2-b]pyridine,9-chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-

Suppliers and Price of 8-Dechloro-9-chloro-N-methyl Desloratadine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
8-Dechloro-9-chloro-N-methylDesloratadine
5mg
$ 195.00

Biosynth Carbosynth
8-Dechloro-9-chloro-N-methyl desloratadine
5 mg
$ 318.00

Biosynth Carbosynth
8-Dechloro-9-chloro-N-methyl desloratadine
2 mg
$ 174.90

Biosynth Carbosynth
8-Dechloro-9-chloro-N-methyl desloratadine
50 mg
$ 1911.00

Biosynth Carbosynth
8-Dechloro-9-chloro-N-methyl desloratadine
25 mg
$ 1051.50

Biosynth Carbosynth
8-Dechloro-9-chloro-N-methyl desloratadine
10 mg
$ 578.20

American Custom Chemicals Corporation
8-DECHLORO-9-CHLORO-N-METHYL DESLORATADINE 95.00%
5MG
$ 505.23

Total 11 raw suppliers

Chemical Property of 8-Dechloro-9-chloro-N-methyl Desloratadine

Chemical Property:

PSA：16.13000
LogP:4.29900
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:324.1393264
Heavy Atom Count:23
Complexity:451

Purity/Quality:

97% ^*data from raw suppliers

8-Dechloro-9-chloro-N-methylDesloratadine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=CC(=C3)Cl)CC1
Uses Loratadine (L469575) Impurity. An isomer of N-Methyl Desloratadine (M316500) with antianaphylactic and antihistaminic activity.

Technology Process of 8-Dechloro-9-chloro-N-methyl Desloratadine

There total 8 articles about 8-Dechloro-9-chloro-N-methyl Desloratadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3964-84-9
7-Chlor-10,11-dihydro-4-aza-5H-dibenzocyclohepten-5-on

: 38092-88-5
9-chloro azatadine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -40 °C

2: H₂SO₄

With sulfuric acid; In tetrahydrofuran;
DOI:10.1021/jm00105a069

Reference yield:

: 32998-95-1
N-tert-butyl-3-methylpyridine-2-carboxamide

: 38092-88-5
9-chloro azatadine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, -40 deg C

2: POCl₃ / Heating

3: PPA / Heating

4: tetrahydrofuran / -40 °C

5: H₂SO₄

With n-butyllithium; sulfuric acid; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/jm00105a069

Reference yield:

: 31255-55-7
3-(4-chloro-phenethyl)-pyridine-2-carbonitrile

: 38092-88-5
9-chloro azatadine

Guidance literature:: Multi-step reaction with 3 steps

1: PPA / Heating

2: tetrahydrofuran / -40 °C

3: H₂SO₄

With sulfuric acid; In tetrahydrofuran;
DOI:10.1021/jm00105a069