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Clarithromycin N-oxide

Base Information Edit
  • Chemical Name:Clarithromycin N-oxide
  • CAS No.:118074-07-0
  • Molecular Formula:C38H69NO14
  • Molecular Weight:763.964
  • Hs Code.:2932206000
  • DSSTox Substance ID:DTXSID30891488
  • Nikkaji Number:J543.807A
  • Wikidata:Q63409253
  • Mol file:118074-07-0.mol
Clarithromycin N-oxide

Synonyms:Clarithromycin N-oxide;118074-07-0;(2S,3R,4S,6R)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-3-hydroxy-N,N,6-trimethyloxan-4-amine oxide;clarithromycin-N-oxide;SCHEMBL8010399;DTXSID30891488;MFCD24386630;Clarithromycin N-oxide, analytical standard;NS00000635;Q63409253;Clarithromycin Impurity Q, United States Pharmacopeia (USP) Reference Standard;6-O-Methyl-erythromycin N-Oxide;Oxacyclotetradecane, erythromycin deriv.

Suppliers and Price of Clarithromycin N-oxide
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Clarithromycin N-oxide
  • 100mg
  • $ 1295.00
  • TRC
  • Clarithromycin N-oxide
  • 10mg
  • $ 160.00
  • Sigma-Aldrich
  • Clarithromycin N-oxide analytical standard
  • 25mg
  • $ 265.00
  • Sigma-Aldrich
  • Clarithromycin Impurity Q United States Pharmacopeia (USP) Reference Standard
  • 10mg
  • $ 1290.00
  • Sigma-Aldrich
  • Clarithromycin Impurity Q Pharmaceutical Secondary Standard; Certified Reference Material
  • 20mg
  • $ 565.00
  • Biosynth Carbosynth
  • Clarithromycin Impurity Q
  • 100 mg
  • $ 365.00
  • Biosynth Carbosynth
  • Clarithromycin Impurity Q
  • 500 mg
  • $ 1080.00
  • Biosynth Carbosynth
  • Clarithromycin Impurity Q
  • 250 mg
  • $ 700.00
  • Biosynth Carbosynth
  • Clarithromycin Impurity Q
  • 50 mg
  • $ 237.00
  • Biosynth Carbosynth
  • Clarithromycin Impurity Q
  • 25 mg
  • $ 154.00
Total 9 raw suppliers
Chemical Property of Clarithromycin N-oxide Edit
Chemical Property:
  • PKA:12.50±0.60(Predicted) 
  • PSA:209.10000 
  • LogP:2.47320 
  • Storage Temp.:?20°C 
  • Solubility.:Chloroform (Slightly) 
  • XLogP3:3.2
  • Hydrogen Bond Donor Count:4
  • Hydrogen Bond Acceptor Count:14
  • Rotatable Bond Count:8
  • Exact Mass:763.47180587
  • Heavy Atom Count:53
  • Complexity:1240
Purity/Quality:

98% *data from raw suppliers

Clarithromycin N-oxide *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)[N+](C)(C)[O-])O)(C)OC)C)C)O)(C)O
  • Isomeric SMILES:CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)[N+](C)(C)[O-])O)(C)OC)C)C)O)(C)O
  • Uses Clarithromycin N-oxide is an urinary metabolite of Clarithromycin (C559750), a macrolide antibiotic. Clarithromycin N-oxide (Clarithromycin EP Impurity Q) is an urinary metabolite of Clarithromycin (C559750), a macrolide antibiotic.
Technology Process of Clarithromycin N-oxide

There total 3 articles about Clarithromycin N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With dihydrogen peroxide; In methanol; water; at 20 ℃; for 15h;
Guidance literature:
With potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; at 5 ℃; for 1h;
Guidance literature:
upstream raw materials:

erythromycin A N-oxide

methyl iodide

clarithromycin

Downstream raw materials:

C50H74O16S

clarithromycin

Refernces Edit
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