IKK epsilon-IN-1

Base Information

Chemical Name:IKK epsilon-IN-1
CAS No.:1292310-49-6
Molecular Formula:C26H27N5O3
Molecular Weight:457.532
Hs Code.:
Mol file:1292310-49-6.mol

Synonyms:IKK epsilon-IN-1;IKKε-IN-1;5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile IKKε-IN-1;5-(2-((4-Morpholinophenyl)Amino)Pyrimidin-4-Yl)-2-((Tetrahydro-2H-Pyran-4-Yl)Oxy)Benzonitrile

Suppliers and Price of IKK epsilon-IN-1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
IKK(epsilon)-IN-1(IKKE-IN-1) >98%
100 mg
$ 400.00

DC Chemicals
IKK(epsilon)-IN-1(IKKE-IN-1) >98%
1 g
$ 1400.00

DC Chemicals
IKK(epsilon)-IN-1(IKKE-IN-1) >98%
250 mg
$ 700.00

Crysdot
IKKε-IN-1 98+%
250mg
$ 1416.00

Crysdot
IKKε-IN-1 98+%
50mg
$ 472.00

ChemScene
TBK1/IKKε-IN-2 98.70%
10mg
$ 600.00

ChemScene
TBK1/IKKε-IN-2 98.70%
5mg
$ 420.00

ChemScene
TBK1/IKKε-IN-2 98.70%
50mg
$ 1800.00

ChemScene
TBK1/IKKε-IN-2 98.70%
100mg
$ 2520.00

ApexBio Technology
IKKε-IN-1
50mg
$ 2363.00

Total 21 raw suppliers

Chemical Property of IKK epsilon-IN-1

Chemical Property:

Boiling Point:727.2±70.0 °C(Predicted)
PKA:5.25±0.40(Predicted)
PSA：92.53000
Density:1.32±0.1 g/cm3(Predicted)
LogP:4.29128

Purity/Quality:

99%, ^*data from raw suppliers

IKK(epsilon)-IN-1(IKKE-IN-1) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

Technology Process of IKK epsilon-IN-1

There total 6 articles about IKK epsilon-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2524-67-6,86759-37-7
4-morpholino-4-yl-phenylamine

: 1292317-55-5
5-(2-chloropyrimidin-4-yl)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

: 1292310-49-6
5-[2-[(4-morpholinophenyl)amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile

Guidance literature:: In 1,4-dioxane; ethanol; at 80 ℃; for 72h; Inert atmosphere;

Reference yield:

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1292310-49-6
5-[2-[(4-morpholinophenyl)amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 90 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 90 °C

4: 1,4-dioxane; ethanol / 72 h / 80 °C / Inert atmosphere

With potassium acetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 179897-89-3
5-Bromo-2-fluoro-benzonitrile

: 1292310-49-6
5-[2-[(4-morpholinophenyl)amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 45 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 90 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 90 °C

4: 1,4-dioxane; ethanol / 72 h / 80 °C / Inert atmosphere

With potassium acetate; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;