1292317-55-5

Upstream product

• 876918-62-6 5-bromo-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 3934-20-1 2,6-Dichloropyrimidine 
• 1292317-54-4 2-((tetrahydro-2H-pyran-4-yl)oxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 2081-44-9 Tetrahydro-pyran-4-ol 

Downstream Products

• 1292310-49-6 5-[2-[(4-morpholinophenyl)amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile 
• 1292312-86-7 methyl 4-[[4-(3-cyano-4-tetrahydropyran-4-yloxy-phenyl)pyrimidin-2-yl]amino]-2-methoxy-benzoate 
• 1292315-74-2 5-[2-[[4-(imidazol-1-ylmethyl)phenyl]amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile 
• 1292317-80-6 4-({4-[3-cyano-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]pyrimidin-2-yl}amino)-2-methoxybenzoic acid 
• 1292315-72-0 5-[2-[[4-(hydroxymethyl)-3-methoxy-phenyl]amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile 
• 1292312-29-8 5-{2-[4-(4-methylpiperazin-1-yl)phenylamino]pyrimidin-4-yl}-2-(tetrahydro-pyran-4-yloxy)benzonitrile 
• 1403247-78-8 5-{2-[(5-{[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}thiophen-2-yl)amino]pyrimidin-4-yl}-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile 
• 1403246-79-6 5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile 
• 1403247-76-6 5-(2-{[5-(morpholin-4-yl)pyridin-2-yl]amino}pyrimidin-4-yl)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile 

Relevant academic research and scientific papers

PYRIMIDINE TBK/IKKε INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

BENZONITRILE DERIVATIVES AS KINASE INHIBITORS

Compounds of the formula I, in which R1, R2, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.

COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS

The invention relates to compounds, pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating diseases and disorders.

AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON

The invention relates to certain aminopyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).