2-broMo-3-(hydroxyMethyl)benzonitrile

Base Information

• Chemical Name: 2-broMo-3-(hydroxyMethyl)benzonitrile
• CAS No.: 1086429-88-0
• Molecular Formula: C8H6BrNO
• Molecular Weight: 212.046
• Mol file: 1086429-88-0.mol

Synonyms:2-broMo-3-(hydroxyMethyl)benzonitrile

Chemical Property of 2-broMo-3-(hydroxyMethyl)benzonitrile

Chemical Property:

• PSA: 44.02000
• LogP: 1.81308
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3-(hydroxymethyl)benzonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-broMo-3-(hydroxyMethyl)benzonitrile

There total 4 articles about 2-broMo-3-(hydroxyMethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-3-cyanobenzyl acetate (1268335-56-3) → C8H6BrNO (1086429-88-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2010.12.034

Reference yield:

2-iodo-3-methylbenzonitrile (52107-70-7) → C8H6BrNO (1086429-88-0) + C8H6INO (1086429-85-7)

Guidance literature:

2-iodo-3-methylbenzonitrile; With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 85 ℃; for 22h; Inert atmosphere;

With sodium hydrogencarbonate; In dimethyl sulfoxide; at 20 - 100 ℃; Inert atmosphere;

DOI:10.1021/ol801986m

Reference yield:

2-bromo-3-(bromomethyl)benzonitrile (1086429-87-9) → C8H6BrNO (1086429-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 1 h / 80 °C

2: lithium hydroxide / tetrahydrofuran; methanol; water / 1 h / 20 °C

With lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.034

upstream raw materials:

2-iodo-3-methylbenzonitrile

2-bromo-3-(bromomethyl)benzonitrile

2-bromo-3-cyanobenzyl acetate

Downstream raw materials:

2-bromo-3-cyanobenzaldehyde

C₁₀H₈BrNO

C₉H₆BrNO

C₉H₈BrNO