2-(3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl)pyrimidine

Base Information

Chemical Name:2-(3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl)pyrimidine
CAS No.:1349864-00-1
Molecular Formula:C₁₈H₁₈ClN₅
Molecular Weight:339.827
Hs Code.:
Mol file:1349864-00-1.mol

Synonyms:2-(3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl)pyrimidine

Suppliers and Price of 2-(3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl)pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl)pyrimidine

There total 5 articles about 2-(3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1349863-97-3
tert-butyl 4-[3-(4-chlorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidine-1-carboxylate

: 1349864-00-1
2-[3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl]pyrimidine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1349864-00-1
2-[3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / dichloromethane / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 1.5 h / -78 - 0 °C

3.1: hydrazine; triethylamine / ethanol / 3 h / 75 °C

4.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / ethanol / 1.5 h / 120 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; dmap; copper(l) iodide; n-butyllithium; 1,10-Phenanthroline; caesium carbonate; triethylamine; hydrazine; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane;

Reference yield:

: 1349863-93-9
tert-butyl 4-[3-(4-chlorophenyl)prop-2-ynoyl]piperidine-1-carboxylate

: 1349864-00-1
2-[3-(4-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-1-yl]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine; triethylamine / ethanol / 3 h / 75 °C

2: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / ethanol / 1.5 h / 120 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; triethylamine; hydrazine; In 1,4-dioxane; ethanol; dichloromethane;