N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide

Base Information

Chemical Name:N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide
CAS No.:402470-91-1
Molecular Formula:C13H17NO2
Molecular Weight:219.283
Hs Code.:2924299090
European Community (EC) Number:609-802-0
UNII:H8SGM8LKMI
DSSTox Substance ID:DTXSID80432204
Nikkaji Number:J1.674.518I
Wikidata:Q27279774
Mol file:402470-91-1.mol

Synonyms:N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide;402470-91-1;N,N-dimethyl-4-(4-methylphenyl)-4-oxobutanamide;H8SGM8LKMI;N,N-Dimethyl-3-(4-methylbenzoyl)propionamide;UNII-H8SGM8LKMI;SCHEMBL4883159;DTXSID80432204;BCP31590;AKOS015998861;CS-0281238;Benzenebutanamide, N,N,4-trimethyl-gamma-oxo-;N,N-Dimethyl-4-oxo-4-(4-methylphenyl)butanamide;ZOLPIDEM TARTRATE IMPURITY F [EP IMPURITY];N,N,4-TRIMETHYL-.GAMMA.-OXOBENZENEBUTANAMIDE;Q27279774;Z32014322;BENZENEBUTANAMIDE, N,N,4-TRIMETHYL-.GAMMA.-OXO-;N,N-DIMETHYL 4-(4-METHYLPHENYL)-4-OXOBUTANAMIDE

Suppliers and Price of N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide
250mg
$ 105.00

TRC
N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide
1g
$ 290.00

Biosynth Carbosynth
N,N-Dimethyl-3-(4-methylbenzoyl)propionamide
1 g
$ 275.00

Biosynth Carbosynth
N,N-Dimethyl-3-(4-methylbenzoyl)propionamide
500 mg
$ 175.00

Biosynth Carbosynth
N,N-Dimethyl-3-(4-methylbenzoyl)propionamide
250 mg
$ 100.00

Biosynth Carbosynth
N,N-Dimethyl-3-(4-methylbenzoyl)propionamide
100 mg
$ 50.00

Biosynth Carbosynth
N,N-Dimethyl-3-(4-methylbenzoyl)propionamide
2 g
$ 520.00

American Custom Chemicals Corporation
N,N-DIMETHYL-4-OXO-4-(PARA-TOLYL)BUTANAMIDE 95.00%
5MG
$ 502.25

Alichem
N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide
1g
$ 400.00

Total 25 raw suppliers

Chemical Property of N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide

Chemical Property:

PSA：37.38000
LogP:2.04610
Storage Temp.:2-8°C
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:219.125928785
Heavy Atom Count:16
Complexity:253

Purity/Quality:

99%, ^*data from raw suppliers

N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(=O)CCC(=O)N(C)C
Uses N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide is a reactant used for the synthesis of Zolpidem, short term treatment of insomnia.

Technology Process of N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide

There total 4 articles about N,N-Dimethyl-4-oxo-4-(p-tolyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2680-03-7,68761-83-1
N,N-Dimethylacrylamide

: 99-94-5
p-Toluic acid

: 402470-91-1
N,N-dimethyl-4-oxo-4-(4-methylphenyl)butanamide

Guidance literature:: With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In dichloromethane; water; at 20 ℃; for 48h; Inert atmosphere; Irradiation;

Reference yield: 61.0%

: 2680-03-7,68761-83-1
N,N-Dimethylacrylamide

: 104-87-0
4-methyl-benzaldehyde

: 402470-91-1
N,N-dimethyl-4-oxo-4-(4-methylphenyl)butanamide

Guidance literature:: With tributylphosphine; In tetrahydrofuran; for 2h; Heating;
DOI:10.1016/S0040-4039(01)02344-9

Reference yield:

: 4619-20-9
3-(4-methylbenzoyl)propionic acid

: 402470-91-1
N,N-dimethyl-4-oxo-4-(4-methylphenyl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0.5 h / -20 °C

2: triethylamine / tetrahydrofuran / 1 h / Ambient temperature

With triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00072a010