5-chloropyrazolo[1,5-a]pyrimidin-7-amine

Base Information

Chemical Name:5-chloropyrazolo[1,5-a]pyrimidin-7-amine
CAS No.:245095-96-9
Molecular Formula:C₆H₅ClN₄
Molecular Weight:168.585
Hs Code.:2933990090
Mol file:245095-96-9.mol

Synonyms:5-chloropyrazolo[1,5-a]pyrimidin-7-amine;Pyrazolo[1,5-a]pyrimidin-7-amine, 5-chloro-

Suppliers and Price of 5-chloropyrazolo[1,5-a]pyrimidin-7-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Chloropyrazolo[1,5-A]pyrimidin-7-amine
10mg
$ 45.00

SynChem
5-CHLOROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE 95%
1 g
$ 489.00

Crysdot
5-Chloropyrazolo[1,5-a]pyrimidin-7-amine 95+%
1g
$ 590.00

Chemenu
5-Chloropyrazolo[1,5-a]pyrimidin-7-amine 95+%
1g
$ 990.00

Alichem
5-Chloropyrazolo[1,5-a]pyrimidin-7-amine
10g
$ 2110.50

Alichem
5-Chloropyrazolo[1,5-a]pyrimidin-7-amine
5g
$ 1934.90

AK Scientific
5-Chloropyrazolo[1,5-a]pyrimidin-7-amine
1g
$ 866.00

Total 7 raw suppliers

Chemical Property of 5-chloropyrazolo[1,5-a]pyrimidin-7-amine

Chemical Property:

PSA：56.21000
LogP:1.54610
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

5-Chloropyrazolo[1,5-A]pyrimidin-7-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-chloropyrazolo[1,5-a]pyrimidin-7-amine

There total 2 articles about 5-chloropyrazolo[1,5-a]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 57489-77-7
5,7-dichloropyrazolo[1,5-a]pyrimidine

: 245095-96-9
5-chloropyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: With ammonium hydroxide; at 20 - 85 ℃; Sealed tube;

Reference yield:

: 57489-70-0
5,7-dihydroxypyrazolo[1,5-a]pyrimidine

: 245095-96-9
5-chloropyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / 0 - 60 °C / Inert atmosphere

2: ammonium hydroxide / 20 - 85 °C / Sealed tube

With ammonium hydroxide; N,N-dimethyl-aniline; trichlorophosphate;

Reference yield:

: 245095-96-9
5-chloropyrazolo[1,5-a]pyrimidin-7-amine

: tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 100 °C / Sealed tube; Inert atmosphere

3: hydrogen / palladium on carbon / ethyl acetate / 3 h / 45 °C

4: N-iodo-succinimide / dichloromethane / 1.5 h / 20 °C

5: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 100 °C / Inert atmosphere; Sealed tube

6: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

With N-Bromosuccinimide; N-iodo-succinimide; hydrogen; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on carbon; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 7: Stille Coupling;