(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

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Chemical Name:(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate
CAS No.:1260106-44-2
Molecular Formula:C₄₃H₆₄N₆O₆Si₂
Molecular Weight:817.189
Hs Code.:

(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Synonyms:(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

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Chemical Property of (Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

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Technology Process of (Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

There total 8 articles about (Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yloxy)piperidine-1-carboxylate

: 64724-29-4
tributyl-((Z)-2-ethoxy-vinyl)-stannane

: 1260106-44-2
(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃;

Reference yield:

: 57489-77-7
5,7-dichloropyrazolo[1,5-a]pyrimidine

: 1260106-44-2
(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium hydroxide / 20 - 85 °C / Sealed tube

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C

3.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C

4.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 70 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

5.2: 0.5 h / 100 °C / Microwave irradiation

6.1: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

With ammonium hydroxide; potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; sodium hydride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; 7.1: Stille Coupling;

Reference yield:

: 57489-70-0
5,7-dihydroxypyrazolo[1,5-a]pyrimidine

: 1260106-44-2
(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / 0 - 60 °C / Inert atmosphere

2.1: ammonium hydroxide / 20 - 85 °C / Sealed tube

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C

4.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C

5.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 70 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

6.2: 0.5 h / 100 °C / Microwave irradiation

7.1: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

With ammonium hydroxide; potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; sodium hydride; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; 8.1: Stille Coupling;