5-AMINO-2-FLUOROBENZOIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 5-AMINO-2-FLUOROBENZOIC ACID HYDROCHLORIDE
• CAS No.: 130047-15-3
• Molecular Formula: C7H7ClFNO2
• Molecular Weight: 191.589
• Mol file: 130047-15-3.mol

Synonyms:5-AMINO-2-FLUOROBENZOIC ACID HYDROCHLORIDE

Chemical Property of 5-AMINO-2-FLUOROBENZOIC ACID HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 3.88E-06mmHg at 25°C
• Boiling Point: 370.3°C at 760 mmHg
• Flash Point: 177.8°C
• PSA: 63.32000
• LogP: 2.48930

Purity/Quality:

5-AMINO-2-FLUOROBENZOIC ACID HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-2-FLUOROBENZOIC ACID HYDROCHLORIDE

There total 1 articles about 5-AMINO-2-FLUOROBENZOIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-5-nitrobenzoic acid (7304-32-7) → 3-amino-6-fluorobenzoic acid hydrochloride (130047-15-3)

Guidance literature:

With hydrogenchloride; 10% palladium on activated carbon; hydrogen; In methanol; water; for 0.5h; under 1551.49 Torr;

DOI:10.1021/jm900012a

Reference yield: 65.9%

3-amino-6-fluorobenzoic acid hydrochloride (130047-15-3) + trifluoromethanesulfonic acid anhydride (1025373-45-8) → 2-Fluoro-5-(trifluoromethylsulfamoyl)-benzoic acid methyl ester (130046-65-0)

Guidance literature:

With pyridine; sulfuric acid; In 1,4-dioxane; methanol; 1,1-dichloroethane; water;

Reference yield:

2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetic acid (383661-55-0) + (3R,5S)-N-propanesulfonyl-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetamide (383653-04-1) + 3-amino-6-fluorobenzoic acid hydrochloride (130047-15-3) + isobutyl chloroformate (543-27-1) → methyl 5-[[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethylphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]amino]-2-fluorobenzoate

Guidance literature:

With pyridine; hydrogenchloride; triethylamine; In water; N,N-dimethyl-formamide;

upstream raw materials:

2-fluoro-5-nitrobenzoic acid

Downstream raw materials:

2-Fluoro-5-(trifluoromethylsulfamoyl)-benzoic acid methyl ester