2-(4-Fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(4-Fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 1001200-60-7
• Molecular Formula: C₁₃H₁₈BFO₂
• Molecular Weight: 236.094
• Hs Code.: 2934999090
• Mol file: 1001200-60-7.mol

Synonyms:2-(4-Fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4-Fluoro-3-methylphenylboronic acid, pinacol ester;4-Fluoro-3-Methylbenzeneboronic acid pinacol ester, 96%

Chemical Property of 2-(4-Fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• Boiling Point: 303.4±35.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.04g/ml
• LogP: 2.43330
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Fluoro-3-methylphenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Fluoro-3-methylphenylboronic acid, pinacol ester

Technology Process of 2-(4-Fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 1 articles about 2-(4-Fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) + 4-fluoro-3-methylphenyl boronic acid (139911-27-6) → 2-(4-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (1001200-60-7)

Guidance literature:

In toluene;

DOI:10.1021/jo701888m DOI:10.1016/j.tet.2007.11.030

Reference yield: 76.0%

2-(4-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (1001200-60-7) + tert-butyl 4-(4-bromo-1-(2-hydroxyethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (1226803-00-4) → 4-[4-(4-fluoro-3-methylphenyl)-1-(2-hydroxyethyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid tert-butyl ester (1428252-95-2)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 50 ℃; Inert atmosphere;

upstream raw materials:

2,3-dimethyl-2,3-butane diol

4-fluoro-3-methylphenyl boronic acid

Downstream raw materials:

4-[4-(4-fluoro-3-methylphenyl)-1-(2-hydroxyethyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid tert-butyl ester