N-(tert-butyl)-4-methylbenzamide

Base Information

• Chemical Name: N-(tert-butyl)-4-methylbenzamide
• CAS No.: 42498-32-8
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2924299090
• Mol file: 42498-32-8.mol

Synonyms:N-(tert-butyl)-4-methylbenzamide;N-(1,1-Dimethylethyl)-4-methylbenzamide

Chemical Property of N-(tert-butyl)-4-methylbenzamide

Chemical Property:

• PSA: 29.10000
• LogP: 2.91420
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-(tert-Butyl)-4-methylbenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyl)-4-methylbenzamide

There total 38 articles about N-(tert-butyl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic acid tert-butyl ester (540-88-5) + 4-methyl-benzaldehyde (104-87-0) → N-tert-butyl-4-methylbenzamide (42498-32-8)

Guidance literature:

4-methyl-benzaldehyde; With sodium azide; trifluorormethanesulfonic acid; acetic acid; at 40 ℃;

acetic acid tert-butyl ester; With trifluorormethanesulfonic acid; at 40 ℃;

DOI:10.1016/j.tetlet.2016.08.069

Reference yield: 98.0%

4-methyl-benzaldehyde (104-87-0) + tert-butyl alcohol (75-65-0) → N-tert-butyl-4-methylbenzamide (42498-32-8)

Guidance literature:

4-methyl-benzaldehyde; With sodium azide; trifluorormethanesulfonic acid; acetic acid; at 40 ℃; for 2h;

tert-butyl alcohol; With trifluorormethanesulfonic acid; at 40 ℃; for 2h;

DOI:10.1016/j.tetlet.2016.08.069

Reference yield: 95.0%

t-butyl malonate (541-16-2) + para-methylbenzonitrile (104-85-8) → N-tert-butyl-4-methylbenzamide (42498-32-8)

Guidance literature:

With iron (III) perchlorate monohydrate; In neat (no solvent); at 80 ℃; for 2h;

DOI:10.1055/s-0037-1610658

upstream raw materials:

N-tert-butyltoluamidine hydrochloride

4-methyl-benzoyl chloride

tert-butylamine

N-tert-butyl-2-methylpropanimine

Downstream raw materials:

p-Toluic acid

tert-butylamine

4-(bromomethyl)-N-(tert-butyl)benzamide

N-(tert-butyl)-4-formylbenzamide