METHYL 6-AMINO-2,3-DIMETHOXYBENZOATE

Base Information

• Chemical Name: METHYL 6-AMINO-2,3-DIMETHOXYBENZOATE
• CAS No.: 128823-83-6
• Molecular Formula: C10H13NO4
• Molecular Weight: 211.218
• Mol file: 128823-83-6.mol

Synonyms:METHYL 6-AMINO-2,3-DIMETHOXYBENZOATE

Chemical Property of METHYL 6-AMINO-2,3-DIMETHOXYBENZOATE

Chemical Property:

• Melting Point: 49-50 °C
• Boiling Point: 334.3±37.0 °C(Predicted)
• PKA: 2.28±0.10(Predicted)
• PSA: 70.78000
• Density: 1.189±0.06 g/cm3(Predicted)
• LogP: 1.65380

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 6-AMINO-2,3-DIMETHOXYBENZOATE

There total 7 articles about METHYL 6-AMINO-2,3-DIMETHOXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Azidocarbonyl-2,3-dimethoxy-benzoic acid methyl ester (128823-82-5) → methyl 6-amino-2,3-dimethoxybenzoate (128823-83-6)

Guidance literature:

With acetic acid; In water; for 0.5h; Yield given; Heating;

Reference yield:

3,4-dimethoxy-1,2-benzenedicarboxylic acid 2-methyl ester (128823-80-3) → methyl 6-amino-2,3-dimethoxybenzoate (128823-83-6)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 0.5 h

3: glacial acetic acid / H₂O / 0.5 h / Heating

With thionyl chloride; sodium azide; acetic acid; In water; acetone;

Reference yield:

6-Chlorocarbonyl-2,3-dimethoxy-benzoic acid methyl ester (128823-81-4) → methyl 6-amino-2,3-dimethoxybenzoate (128823-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaN₃ / acetone; H₂O / 0.5 h

2: glacial acetic acid / H₂O / 0.5 h / Heating

With sodium azide; acetic acid; In water; acetone;

upstream raw materials:

diazomethane

6-amino-2,3-dimethoxybenzoic acid

methanol

methyl 2-nitro-5,6-dimethoxybenzoate

Downstream raw materials:

3H-6,7-dimethoxyquinazolin-4-one

6,7-dimethoxy-4-chloroquinazoline

6-amino-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid

Refernces