N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(8α,9S)-6'-Methoxycinchonan-9-yl]-Urea

Base Information

Chemical Name:N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(8α,9S)-6'-Methoxycinchonan-9-yl]-Urea
CAS No.:957770-66-0
Molecular Formula:C29H28F6N4O2
Molecular Weight:578.557
Hs Code.:
Mol file:957770-66-0.mol

Synonyms:N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(8α,9S)-6'-Methoxycinchonan-9-yl]-Urea

Suppliers and Price of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(8α,9S)-6'-Methoxycinchonan-9-yl]-Urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(8α,9S)-6'-methoxycinchonan-9-yl]urea, 98%, (99% ee)
50mg
$ 118.00

ChemScene
N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(8α,9S)-6'-methoxycinchonan-9-yl]urea ≥97.0%
100mg
$ 98.00

Arctom
1-(3,5-Bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)urea 97%
100mg
$ 182.00

Total 5 raw suppliers

Chemical Property of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(8α,9S)-6'-Methoxycinchonan-9-yl]-Urea

Chemical Property:

Melting Point:134 - 135 °C
Boiling Point:589.6±50.0 °C(Predicted)
PKA:11.85±0.46(Predicted)
PSA：66.49000
Density:1.38±0.1 g/cm3(Predicted)
LogP:7.44200

Purity/Quality:

97% ^*data from raw suppliers

N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(8α,9S)-6'-methoxycinchonan-9-yl]urea, 98%, (99% ee) ^*data from reagent suppliers

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Technology Process of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(8α,9S)-6'-Methoxycinchonan-9-yl]-Urea

There total 8 articles about N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(8α,9S)-6'-Methoxycinchonan-9-yl]-Urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 16588-74-2
3,5-ditrifluoromethylisocyanate

: 9-amino-9-deoxy-epiquinine

: 957770-66-0
1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)urea

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jacs.7b09124

Reference yield: 76.0%

: 1231763-32-8,18797-90-5
(8α,9S)-6'-methoxycinchonan-9-amine trihydrochloride

: 16588-74-2
3,5-ditrifluoromethylisocyanate

: 957770-66-0
1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)urea

Guidance literature:: (8α,9S)-6'-methoxycinchonan-9-amine trihydrochloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

3,5-ditrifluoromethylisocyanate; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/acs.orglett.6b02398