4,5-DICHLORO-6-ISOPROPYLPYRIMIDINE

Base Information

• Chemical Name: 4,5-DICHLORO-6-ISOPROPYLPYRIMIDINE
• CAS No.: 141602-30-4
• Molecular Formula: C₇H₈Cl₂N₂
• Molecular Weight: 191.06
• Mol file: 141602-30-4.mol

Synonyms:4,5-DICHLORO-6-ISOPROPYLPYRIMIDINE

Chemical Property of 4,5-DICHLORO-6-ISOPROPYLPYRIMIDINE

Chemical Property:

• PSA: 25.78000
• LogP: 2.90680

Purity/Quality:

99% ^*data from raw suppliers

4,5-DICHLORO-6-ISOPROPYLPYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-DICHLORO-6-ISOPROPYLPYRIMIDINE

There total 2 articles about 4,5-DICHLORO-6-ISOPROPYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

n-butyllithium (109-72-8,29786-93-4) + 4,5-Dichloro-6-ethylpyrimidine (115617-41-9) → 4,5-dichloro-6-isopropylpyrimidine (141602-30-4)

Guidance literature:

With diisopropylamine; In tetrahydrofuran; hexane; water;

Reference yield: 67.5%

5-Chloro-4-hydroxy-6-isopropylpyrimidine → 4,5-dichloro-6-isopropylpyrimidine (141602-30-4)

Guidance literature:

With trichlorophosphate; at 90 ℃; for 3h;

DOI:10.1021/acs.jafc.1c00236

Reference yield: 53.0%

[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanamine hydrochloride + 4,5-dichloro-6-isopropylpyrimidine (141602-30-4) → 5-chloro-6-isopropyl-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-4-amine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; for 8h; Reflux;

DOI:10.1021/acs.jafc.1c00236

upstream raw materials:

n-butyllithium

4,5-Dichloro-6-ethylpyrimidine

Refernces

• 1、 -. "PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME". . . Retrieved 2008/06/13.