4,5-DibroMo-2-Methyl-2H-1,2,3-triazole

Base Information

• Chemical Name: 4,5-DibroMo-2-Methyl-2H-1,2,3-triazole
• CAS No.: 28938-17-2
• Molecular Formula: C3H3Br2N3
• Molecular Weight: 240.885
• Hs Code.: 2933990090
• Mol file: 28938-17-2.mol

Synonyms:4,5-DibroMo-2-Methyl-2H-1,2,3-triazole;4,5-dibromo-2-methyl-1,2,3-triazole;4,5-dibromo-2-methyltriazole;4,5-dibromo-2-methyl-triazole;2-Methyl-4,5-dibromo-2H-1,2,3-triazole

Chemical Property of 4,5-DibroMo-2-Methyl-2H-1,2,3-triazole

Chemical Property:

• PSA: 30.71000
• LogP: 1.34010
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4,5-Dibromo-2-methyl-2H-[1,2,3]triazole 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DibroMo-2-Methyl-2H-1,2,3-triazole

There total 7 articles about 4,5-DibroMo-2-Methyl-2H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

4,5-Dibromo-1H-1,2,3-triazole (15294-81-2) + methyl iodide (74-88-4) → 2-methyl-4,5-dibromo-2H-1,2,3-triazole (28938-17-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 60.8%

1-methyl-4,5-dibromo-1H-1,2,3-triazole (25537-64-8) → 2-methyl-4,5-dibromo-2H-1,2,3-triazole (28938-17-2)

Guidance literature:

In water; isopropyl alcohol; at 25 - 50 ℃; for 5h;

Reference yield: 60.0%

4,5-Dibromo-1H-1,2,3-triazole (15294-81-2) + methyl iodide (74-88-4) → 2-methyl-4,5-dibromo-2H-1,2,3-triazole (28938-17-2) + 1-methyl-4,5-dibromo-1H-1,2,3-triazole (25537-64-8)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 110 ℃; for 1h; Temperature; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1055/s-0040-1707163

upstream raw materials:

1-methyl-1,2,5-triazole

4,5-Dibromo-1H-1,2,3-triazole

methyl iodide

4,5-dibromo-2H-1,2,3-triazole

Downstream raw materials:

4-bromo-2,5-dimethyltriazole

4-bromo-1,5-dimethyl-1H-1,2,3-triazole

4-bromo-2-methyl-2H-1,2,3-triazole

Refernces

• 1、 Albright, Savannah G.,Ali, Bakr,Chapman, Hayley A.,Cheng, Yijie,Cusic, Rachel M.,Friese, Seth J.,Hartlove, Nathan B.,Labb, Samantha A.,Marr, Alissa N.,Masteran, Conner J.,Timmons, Miranda. "Synthesis of a Water-Soluble, Soft N-Donor BTzBP Ligand Containing only CHON". supporting information. p. 1384 - 1388. Retrieved 2020/08/03.
• 2、 -. "DIHYDROPYRROLOPYRAZINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER". Page/Page column 68. . Retrieved 2017/05/28.