4-[[[(4-nitrophenyl)methoxy]carbonyl]-2-propen-1-ylamino]-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-[[[(4-nitrophenyl)methoxy]carbonyl]-2-propen-1-ylamino]-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:235420-67-4
Molecular Formula:C₂₁H₂₉N₃O₆
Molecular Weight:419.478
Hs Code.:
Mol file:235420-67-4.mol

Synonyms:4-[[[(4-nitrophenyl)methoxy]carbonyl]-2-propen-1-ylamino]-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester

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Chemical Property of 4-[[[(4-nitrophenyl)methoxy]carbonyl]-2-propen-1-ylamino]-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-[[[(4-nitrophenyl)methoxy]carbonyl]-2-propen-1-ylamino]-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 2 articles about 4-[[[(4-nitrophenyl)methoxy]carbonyl]-2-propen-1-ylamino]-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 235420-68-5
1-(t-butoxycarbonyl)-4-(N-prop-2-enyl)aminopiperidine

: 4457-32-3
4-nitrobenzyl chloroformate

: 235420-67-4
1-(tert-butoxycarbonyl)-4-(N-(4-nitrobenzyloxycarbonyl)-N-(allyl)amino)piperidine

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 235420-67-4
1-(tert-butoxycarbonyl)-4-(N-(4-nitrobenzyloxycarbonyl)-N-(allyl)amino)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: HOAc; NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

2: DIPEA / CH₂Cl₂ / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(01)00492-9

Reference yield:

: 235420-67-4
1-(tert-butoxycarbonyl)-4-(N-(4-nitrobenzyloxycarbonyl)-N-(allyl)amino)piperidine

: 413603-60-8
4-nitrobenzyl allyl(piperidin-4-yl)carbamate

Guidance literature:: 1-(tert-butoxycarbonyl)-4-(N-(4-nitrobenzyloxycarbonyl)-N-(allyl)amino)piperidine; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With water; sodium hydroxide; In dichloromethane;