4-ALLYLAMINO PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-ALLYLAMINO PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 235420-68-5
• Molecular Formula: C13H24 N2 O2
• Molecular Weight: 240.346
• Mol file: 235420-68-5.mol

Synonyms:1-Piperidinecarboxylicacid, 4-(2-propenylamino)-, 1,1-dimethylethyl ester (9CI);4-Allylaminopiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl4-(allylamino)piperidine-1-carboxylate

Chemical Property of 4-ALLYLAMINO PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.000207mmHg at 25°C
• Refractive Index: 1.493
• Boiling Point: 327°Cat760mmHg
• Flash Point: 151.6°C
• PSA: 41.57000
• Density: 1g/cm³
• LogP: 2.49030

Purity/Quality:

99% ^*data from raw suppliers

4-ALLYLAMINO PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ALLYLAMINO PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 3 articles about 4-ALLYLAMINO PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 1-amino-2-propene (107-11-9,30551-89-4) → 1-(t-butoxycarbonyl)-4-(N-prop-2-enyl)aminopiperidine (235420-68-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2010.10.033

Reference yield: 97.0%

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) + allyl bromide (106-95-6) → 1-(t-butoxycarbonyl)-4-(N-prop-2-enyl)aminopiperidine (235420-68-5)

Guidance literature:

1-(tert-butoxycarbonyl)-4-aminopiperidine; With potassium carbonate; potassium iodide; at 20 ℃; for 0.166667h; Inert atmosphere;

allyl bromide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.09.040

Reference yield:

→ 1-(t-butoxycarbonyl)-4-(N-prop-2-enyl)aminopiperidine (235420-68-5)

Guidance literature:

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

1-amino-2-propene

1-(tert-butoxycarbonyl)-4-aminopiperidine

allyl bromide

Downstream raw materials:

C₁₇H₂₂F₃N₃O

C₂₂H₂₉F₃N₂O₅

C₂₂H₃₂N₂O₆S

C₂₃H₃₂N₂O₆

Refernces

• 1、 Duan, Maosheng,Peckham, Jennifer,Edelstein, Mark,Ferris, Robert,Kazmierski, Wieslaw M.,Spaltenstein, Andrew,Wheelan, Pat,Xiong, Zhiping. "Discovery of N-benzyl-N′-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (I): Optimization of the amine portion". scheme or table. p. 7397 - 7400. Retrieved 2011/02/23.
• 2、 -. "PYROLLIDINE-BASED COMPOUNDS". Page/Page column 59. . Retrieved 2009/08/16.