1-Phenethylcyclohexanol

Base Information

• Chemical Name: 1-Phenethylcyclohexanol
• CAS No.: 124620-30-0
• Molecular Formula: C14H20O
• Molecular Weight: 204.312
• Mol file: 124620-30-0.mol

Synonyms:1-(2-Phenylethyl)cyclohexanol;1-Phenethylcyclohexanol

Chemical Property of 1-Phenethylcyclohexanol

Chemical Property:

• Melting Point: 55-56 °C
• Boiling Point: 165 °C(Press: 10 Torr)
• PKA: 15.17±0.20(Predicted)
• PSA: 20.23000
• Density: 1.020±0.06 g/cm3(Predicted)
• LogP: 3.31440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenethylcyclohexanol

There total 9 articles about 1-Phenethylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 2-phenylethyl chloride (622-24-2) → 1-phenethyl-cyclohexanol (124620-30-0)

Guidance literature:

With thulium(II) iodide; at 25 ℃; for 0.05h;

DOI:10.1021/ja992951m

Reference yield: 94.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 1-phenyl-2-bromoethane (103-63-9) → 1-phenethyl-cyclohexanol (124620-30-0)

Guidance literature:

With thulium(II) iodide; at -22 ℃; for 1h;

DOI:10.1021/ja992951m

Reference yield: 94.0%

1-hydroxy-1-cyclohexanecarbonitrile (931-97-5) + phenethylmagnesium chloride (90878-19-6) → 1-phenethyl-cyclohexanol (124620-30-0)

Guidance literature:

In tetrahydrofuran; at 0 - 35 ℃; for 16h;

DOI:10.1246/bcsj.20110270

upstream raw materials:

phenethylmagnesium bromide

cyclohexanone

phenethylmagnesium chloride

ethyl dihydrocinnamate

Downstream raw materials:

(2-(cyclohex-1-en-1-yl)ethyl)benzene

1-(phenethyl)cyclohexylamine hydrochloride

cis-1,2,3,4,4a,9,10,10a-octahydrophenanthren-9-one

Refernces

• 1、 Evans, William J.,Allen, Nathan T.. "Ketone coupling with alkyl iodides, bromides, and chlorides using thulium diiodide: A more powerful version of SmI2(THF)(x)/HMPA". . p. 2118 - 2119. Retrieved 2000.
• 2、 Sakai, Takahiro,Soeta, Takahiro,Inomata, Katsuhiko,Ukaji, Yutaka. "Strecker-type reaction of nitrones using cyanohydrin". scheme or table. p. 231 - 235. Retrieved 2012/04/23.
• 3、 Evans, William J.,Workman, Penny S.,Allen, Nathan T.. "Utility of neodymium diiodide as a reductant in ketone coupling reactions". . p. 2041 - 2042. Retrieved 2007/10/03.