1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-3-(trifluoroMethyl)-

Base Information

Chemical Name:1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-3-(trifluoroMethyl)-
CAS No.:892414-50-5
Molecular Formula:C₈H₃ClF₃N₃O₂
Molecular Weight:265.579
Hs Code.:

Synonyms:1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-3-(trifluoroMethyl)-;1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-3-(trifluoroMethyl)-7

Suppliers and Price of 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-3-(trifluoroMethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 7 raw suppliers

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-3-(trifluoroMethyl)-

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-3-(trifluoroMethyl)-

There total 7 articles about 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-3-(trifluoroMethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 892414-49-2
4-nitro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 7-oxide

: 892414-50-5
6-chloro-4-nitro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetyl chloride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1055/s-2006-958935

Reference yield:

: 932406-33-2
2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethane-1,1-diol

: 892414-50-5
6-chloro-4-nitro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 290 g / potassium carbonate / tetrahydrofuran / 20 °C

2: 81 percent / H₂ / Raney-nickel / ethanol / 20 °C

3: 83 percent / thionyl chloride; pyridine / CH₂Cl₂ / 20 °C

4: 79 percent / m-chloroperbenzoic acid / ethyl acetate / 1 h / 0 °C

5: 76 percent / aq. nitric acid / trifluoroacetic acid / 2 h / 70 °C

6: 100 percent / hexamethyldisilazane; trichloroacetyl chloride / tetrahydrofuran / 0 - 20 °C

With pyridine; thionyl chloride; hydrogen; nitric acid; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetyl chloride; nickel; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; trifluoroacetic acid; 1: Henry reaction;
DOI:10.1055/s-2006-958935

Reference yield:

: 892414-45-8
1,1,1-trifluoro-2-(2-fluoropyridin-3-yl)-3-nitropropan-2-ol

: 892414-50-5
6-chloro-4-nitro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / H₂ / Raney-nickel / ethanol / 20 °C

2: 83 percent / thionyl chloride; pyridine / CH₂Cl₂ / 20 °C

3: 79 percent / m-chloroperbenzoic acid / ethyl acetate / 1 h / 0 °C

4: 76 percent / aq. nitric acid / trifluoroacetic acid / 2 h / 70 °C

5: 100 percent / hexamethyldisilazane; trichloroacetyl chloride / tetrahydrofuran / 0 - 20 °C

With pyridine; thionyl chloride; hydrogen; nitric acid; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetyl chloride; nickel; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; trifluoroacetic acid;
DOI:10.1055/s-2006-958935